Constantinos T. Sofocleous, MD, PhD
Interventional Oncology; Interventional Radiology; Image-Guided Therapies
New Patient Appointments
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Dr. Sofocleous accepts the following list of insurance providers. Select your insurance provider to see more details.
Memorial Sloan Kettering is an in-network provider with Aetna HMO, POS, and PPO plans. Aetna does not include us in any of the plans you can purchase through the insurance exchanges or through Medicare. Please ask your insurance if you need a one-time referral. MSK has an agreement with the Aetna Transplant Program for all Aetna's commercial products.
In New York State
Memorial Sloan Kettering is an in-network provider with Empire Blue Cross Blue Shield (Wellpoint) of New York HMO, EPO, PPO, and POS plans, with the following exceptions:
- Empire Blue Cross Blue Shield does not include us in any of the plans you can buy through the insurance exchanges.
- Memorial Sloan Kettering is not an in-network provider for Empire's Medicare Managed Care plan known as Mediblue).
- Memorial Sloan Kettering is a designated Center of Excellence by Blue Cross Blue Shield.
In New Jersey
Memorial Sloan Kettering is an in-network provider with some Horizon Blue Cross Blue Shield of New Jersey plans for individuals, families, and small businesses. For example, the PPO plan is in-network with our Manhattan locations.
Horizon Blue Cross HMO is only in-network with our Basking Ridge, Bergen and Monmouth locations. It does not allow access to our Manhattan facilities.
Horizon Blue Cross PPO is in network with our Basking Ridge, Bergen, Monmouth and Manhattan locations.
OMNIA Plans: Tier I EPO based plan policy is only in-network with our Basking Ridge, Bergen and Monmouth locations and does not allow access to our Manhattan sites. Tier II EPO is only in-network with our Manhattan sites if it is a blue-card plan (there would be a suitcase logo indicating PPO on the front of the card).
Other plans may only be in-network at our Basking Ridge, Bergen or Monmouth locations.
Outside New York State and New Jersey
Some, but not all, Blue Cross Blue Shield plans outside of New York and New Jersey include Memorial Sloan Kettering as an in-network provider. Contact your insurance to find out if your plan provides in-network access to Memorial Sloan Kettering.
We understand that there may be many complexities involved with insurance coverage purchased through the health exchange network of the Affordable Care Act. We’re here to help. If you have questions about how your care will be covered by an insurance provider, or need help navigating a change in coverage, please call us at 646-227-3378; if you are not a resident of New York, you can call us at 866-248-1274. Our team is here to listen to your concerns and assist you in any way we can. We want our care to be as accessible and affordable for as many people as possible.
Memorial Sloan Kettering is an in-network provider with CIGNA's HMO, POS, and PPO plans. CIGNA does not include us in any of the plans you can buy through the insurance exchanges.
- If you are a New York State resident: Please ask your insurance if you need a one-time referral.
- If you live outside of New York State: Please ask your insurance if you have in-network access to Memorial Sloan Kettering.
Memorial Sloan Kettering is an in-network provider with EmblemHealth’s PPO, EPO, POS, HMO plans and Medicare plans. Emblem Health does not include us in any of its Select Care network plans. EmblemHealth includes GHI, HIP, Vytra, and ConnecticCare (in NYS Only). You must bring a referral from your Emblem primary care doctor to your first appointment.
Memorial Sloan Kettering is an in-network provider with HealthFirst’s commercial products; these commercial products are not purchased on the insurance exchanges.
Memorial Sloan Kettering is an in-network provider with HealthSmart’s Accel, HSPC, and HPO networks.
Memorial Sloan Kettering is a designated Center of Excellence by Humana.
Memorial Sloan Kettering is a designated Center of Excellence by Interlink Health Services.
Memorial Sloan Kettering is a designated Center of Excellence by Lifetrac.
Memorial Sloan Kettering is an in-network provider for all MagnaCare health plans except those products you can buy through the insurance exchanges.
In New York: Memorial Sloan Kettering’s New York locations are in-network with the Emblem
In New Jersey: Memorial Sloan Kettering’s New Jersey locations in Basking Ridge, Bergen and Monmouth are in-network with the Horizon Medicare Advantage Plan. This plan is not accepted for care provided at MSK’s New York locations.
If you are enrolled in any other Medicare Advantage plan, please contact your insurance carrier to determine your benefits and coverage at Memorial Sloan Kettering since your access may be limited.
Memorial Sloan Kettering is an in-network provider with some Multiplan/Beech Street/PHCS plans. Contact your insurance carrier to find out if your plan provides in-network access to Memorial Sloan Kettering.
Memorial Sloan Kettering is a designated Center of Excellence by Multiplan.
If you are covered by more than one insurance plan, you will want to determine your benefits from both plans. First, you need to determine which one is your primary insurance provider by contacting your employee benefits office or your insurance carriers. After you find out which is your primary insurance provider, you should then contact your insurance carrier to determine if you have access to Memorial Sloan Kettering.
Memorial Sloan Kettering is an in-network provider with some MVP plans. Contact your insurance carrier to find out if your plan provides in-network access to Memorial Sloan Kettering.
Memorial Sloan Kettering is an in-network provider for New York State employees who have enrolled in UnitedHealthcare's Cancer Resource Services. If you have the Empire Plan, you should call Cancer Resources Services at 866-936-6002 to verify and enroll in this coverage.
Memorial Sloan Kettering is in-network with Oscar’s Circle Plus Network, a part of its Small Group Broad line that is offered only to select small business groups. Oscar does not include Memorial Sloan Kettering as an in-network provider for any of its individual plans. Please confirm eligibility with your insurance carrier.
We have agreements with several insurance companies that may provide additional coverage for cancer patients. These benefit programs include:
- AXA Assistance USA
- Beech Street
- Integrated Health Plans
- National Health Administrators
- National Preferred Provider Network
- UnitedHealthcare's Cancer Resource Services
- United Resource Network
- Veterans Choice Program
Memorial Sloan Kettering is an in-network provider with Oxford’s Freedom and Liberty plans as well as the Metro Plan (which is only offered to small business groups and no longer offered as individual plans). Please confirm with your insurance if you need a one-time referral. Note: Oxford’s Medicare Managed Care plan — Secure Horizon — does not include Memorial Sloan Kettering as an in-network provider. Oxford does not include us in any of the plans you can buy through the insurance exchanges.
Memorial Sloan Kettering is an in-network provider with the World Trade Center Health Program.
Memorial Sloan Kettering is an in-network provider with QualCare's PPO and HMO/POS network.
Memorial Sloan Kettering is a designated Center of Excellence by Specialty Care Management.
Hospital and physician services may be covered by TRICARE. Please call your TRICARE plan to confirm coverage at Memorial Sloan Kettering.
Memorial Sloan Kettering is an in-network provider with UnitedHealthCare's HMO, POS, and PPO plans. Please confirm with your insurance if a one-time referral is needed.
UnitedHealthCare's Medicare Managed Care plan does not include Memorial Sloan Kettering as an in-network provider.
United does not include us in any of the plans you can buy through the insurance exchanges.
Memorial Sloan Kettering is a designated Center of Excellence by UnitedHealthcare.
Contact and Location
Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offers many services, including screening, chemotherapy, and medical testing.
MD, PhD, University of Athens School of Medicine (Greece)
St. Luke's-Roosevelt Hospital Center; Columbia University College of Physicians and Surgeons
NYU Medical Center
Radiology; CAQ Vascular and Interventional Radiology
I am an interventional radiologist specializing in interventional oncology, caring for people with cancer. I have been practicing interventional radiology since 1998 and joined the Interventional Radiology Service at Memorial Sloan Kettering in 2002. As an expert in interventional oncology, I use minimally invasive, image-guided procedures to diagnose and treat patients with cancer with minimal side effects, complications, and discomfort.
My expertise include the treatment of primary and metastatic liver and lung cancers using thermal ablation (radiofrequency, microwave, cryoablation) or other non-thermal sources of energy (NanoKnife ® or irreversible electroporation). I also specialize in catheter-directed therapies that treat malignant liver tumors that cannot be removed through surgery or destroyed locally (ablation). These treatments include embolization techniques that use beads alone or combined with chemotherapy or radiotherapy delivered directly into liver tumors. These beads combine the therapeutic effects of radiation (radio embolization or selective internal radiation therapy) or chemotherapy (DEB-TACE or chemoembolization) with that of small particle tumor microvasculature embolization. These approaches offer the best therapeutic option to people with cancer who are not candidates for surgery or ablation.
I lecture nationally and internationally on topics such as embolization, radio embolization, and ablation of liver tumors — particularly metastases from colorectal, breast, or other primary cancers as well as hepatocellular cancer. I have also lectured extensively on ablation as a treatment for primary and metastatic lung cancers.
I am involved in several multidisciplinary clinical, research, and educational activities at MSK. As a faculty member on the hepatobiliary, colorectal, and solid-tumor teams, I work very closely with a team of hepatobiliary, colon, and thoracic surgeons; gastrointestinal, breast, and other oncologists; and gastroenterologists and radiation therapists to determine the most appropriate treatment for patients with primary and metastatic cancer of the liver and lung. I am also a current member of the Institutional Review Board, which is responsible for reviewing all human subjects’ related research and monitoring ongoing research conducted at MSK to ensure compliance with regulations.
My research interest is the assessment, validation, and development of biomarkers and surrogate imaging biomarkers. These can predict outcomes and help stratify patients undergoing ablation and imaging-guided locoregional therapies of tumors in general, and particularly in colon cancer metastases. I have published extensively on the treatment of colorectal, neuroendocrine, and breast cancer liver metastases treated by image-guided therapies including radiofrequency and microwave ablation, irreversible electroporation, small particle bland embolization, and radio embolization or selective internal radiation therapy with Yttrium 90 microspheres. I have also studied and published on the cellullar effects of ablation on liver tumors, the use of embolization to salvage infusion pumps in patients with colon cancer metastatic to the liver, and the use of drug eluding beads (DEB-TACE) to treat primary liver cancer. Currently, I am the MSK site primary investigator, along with medical oncologist Andrea Cercek, of a new multi-institutional, randomized controlled trial where we assess the value of treating people with colorectal cancer liver metastases with Yttrium 90 glass microspheres in addition to standard of care second-line chemotherapy. I am also the primary investigator of an ongoing study examining tissue before and after thermal ablation of colon cancer liver metastases to detect predictive biomarkers that can impact treatment outcomes. This study was initially supported through an NIH R21 grant and showed that biopsies after radiofrequency ablation can predict outcomes.
Despite my strong interest in research, my main focus remains caring for patients. Every cancer has a unique identity, so treatment must be tailored to each patient and each situation. The environment and philosophy of MSK allow me and my partners in interventional oncology and image-guided therapies to offer each patient the best possible care for their cancer. The combination of excellence in clinical work and research also allows us to design important and pivotal clinical trials that directly translate in the best patient care.
Awards and Honors
- Radiological Society of North America Interventional Radiology Research Trainee Prize (1997)
- Roentgen Resident Research Award (1998)
- Fellow, Society of Interventional Radiology (2005)
- Fellow, Cardiovascular and Interventional Radiological Society of Europe (2013)
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
- Clinical Trials Investigated by Dr. Sofocleous
- A Study Using Tissue Biopsy and PET Scanning to Optimize Thermal Ablation for Colon Cancer Liver Metastases
- Examination of Tissue from Ablated Malignant Liver Metastases to Predict Outcome
Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Research and Publications
Visit PubMed for a full listing of Dr. Sofocleous’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Constantinos T. Sofocleous discloses the following relationships and financial interests:
Terumo Medical Corporation
Provision of Services
Varian Medical Systems
Provision of Services (uncompensated)
If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.