Memorial Hospital Research Laboratories

The Adriana Haimovitz-Friedman Lab

Research

Adriana Haimovitz-Friedman, PhD
Adriana Haimovitz-Friedman, PhD

The focus of my laboratory is to understand how SDRT can initiate an innate response in the local tumor and also contribute to initiation of a response in distant tumors (Abscopal/Adscopal like effects).

In addition, we use combination of SDRT and chemotherapeutic drugs with short acting anti-angiogenic agents, which result in improved tumor response with less overall toxicity.

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The Adriana Haimovitz-Friedman Lab

Publications

Wang F, Li H, Markovsky E, Glass R, de Stanchina E, Powell SN, Schwartz GK, Haimovitz-Friedman A. Pazopanib radio-sensitization of human sarcoma tumors. Oncotarget. 2018 Feb 6;9(10):9311. doi: 10.18632/oncotarget.24281. eCollection 2018 Feb 6.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R. Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation. Cell Signal. 2017 Feb 24; 34:86-91. doi: 10.1016/j.cellsig.2017.02.021. [Epub ahead of print] PMID: 28238856. DOI: 10.1016/j.cellsig.2017.02.021

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN,    Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M. Tumour-specific PI3K inhibition via      nanoparticle-targeted delivery in head and neck squamous cell carcinoma. Nat Commun. 2017 Feb       13;8:14292. doi: 10.1038/ncomms14292. PMID: 28194032.

Jacobi J, Garcia-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Manova K, Fuks Z, Kolesnick R, Haimovitz-Friedman A. Targeting acid sphingomyelinase with anti-angiogenic chemotherapy. Cell Signal. 2016 Oct 1. pii: S0898-6568(16)30236-4. doi: 10.1016/j.cellsig.2016.09.010. [Epub ahead of print] PMID: 27702691

Mizrachi A, Cotrim AP, Katabi N, Mitchel JB, Verheij M, Haimovitz-Friedman A. Radiation-induced microvascular injury as a mechanism of salivary gland hypofunction and potential target for radioprotectors. Radiat Res. 2016 Aug; 186(2):189-95. doi: 10.1667/RR14431.1. PMID: 27459704

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People

Adriana Haimovitz-Friedman, PhD

Adriana Haimovitz-Friedman, PhD

  • Optimizing the use of Single high Dose Radiation Therapy (SDRT) in pre-clinical studies to activate innate immune signaling pathways, potentially leading to adaptive immune responses within the local tumors and in distant ones, i.e eliciting Adscopal and/or Abscopal effects.
[email protected]
Email Address
(646) 888-2175
Office Phone

Members

Yang Bai

Weill Cornell PhD Student

Chloe Bodden

Lab Technician

Hongyan Li

Research Associate

Ela Markovsky, PhD
Ela Markovsky

Postdoctoral Research Fellow

Mickael Francois Mathieu, Research Fellow
Mickael Francois Mathieu

Research Fellow

Heerim Nam

Visiting Associate Attending Radiation Oncologist from Seoul, Korea

Prerna Nepali
Prerna Nepali

Research Scholar

Lab Affilations

Achievements

  • Our Laboratory was the first to discover that radiation can induced damage to the plasma membrane of the endothelial cells, which resulted in a paradigm shift in the treatments of radiation and introduced the Single high Dose Radiation therapy, SDRT, in the clinic, which results in cures for those tumors that are otherwise non-responders to conventional fractionated radiation therapy.
  • We found the optimal timing to combine SDRT with anti-angiogenics and with chemotherapy.
  • For both prostate and breast cancers, ATM down regulation can radiosensitize via a specific signal transduction pathway involving de novo ceramide generation.
  • Radiation-induced acute blood-brain barrier disruption is mediated by the acid sphingomyelinase (ASMase) pathway, a major contribution to the radiation and brain drug delivery field.
  • Mice suffering from sepsis can be rescued by protecting the microvasculature.
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  • Mice are protected from Radiation-induced gastrointestinal syndrome by protecting the microvasculature via inhibition of the ASMase/Ceramide pathway.

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Adriana Haimovitz-Friedman discloses the following relationships and financial interests:

  • Ceramedix
    Intellectual Property Rights

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

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