Memorial Hospital Research Laboratories

The Britta Weigelt Lab

Research

Britta  Weigelt, PhD
Britta Weigelt, PhD
Director, Gynecology DMT Research Laboratory

Gynecology DMT Research Laboratory

Our laboratory focuses on the use of high-throughput genomics and functional genomics to identify drivers of rare gynecologic cancer types, and to define the clinical and biological significance of intra-tumor phenotypic and genetic heterogeneity in these tumors. Dr. Weigelt’s laboratory is devising strategies to overcome the challenges posed by intra-tumor genetic heterogeneity, based on state-of-the-art sequencing analyses of circulating cell free (cf)DNA and of single cells. By bringing together traditional pathological techniques with genetic analyses and functional studies, the Weigelt lab seeks to refine the classification of gynecologic cancers and identify novel drivers and potential therapeutic targets of specific tumor types. In addition, Dr. Weigelt is investigating if cfDNA analysis (so-called “liquid biopsies”) can accurately monitor the disease course of women with endometrial or cervical cancer, and if resistance mechanisms to platinum salts or PARP inhibitors in ovarian cancer patients can be identified in cfDNA.

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The Britta  Weigelt Lab

Publications

Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary. Kim SH, Da Cruz Paula A, Basili T, Dopeso H, Bi R, Pareja F, da Silva EM, Gularte-Mérida R, Sun Z, Fujisawa S, Smith CG, Ferrando L, Martins Sebastião AP, Bykov Y, Li A, Silveira C, Ashley CW, Stylianou A, Selenica P, Samore WR, Jungbluth AA, Zamarin D, Abu-Rustum NR, Helin K, Soslow RA, Reis-Filho JS, Oliva E, Weigelt B. Nat Commun 2020; 11:44. doi: 10.1038/s41467-019-13806-x.

Diverse BRCA1 and BRCA2 reversion mutations in circulating cell-free DNA of therapy-resistant breast or ovarian cancer. Weigelt B, Comino-Méndez I, de Bruijn I, Tian L, Meisel JL, García-Murillas I, Fribbens C, Cutts R, Martelotto LG, Ng CKY, Lim RS, Selenica P, Piscuoglio S, Aghajanian C, Norton L, Murali R, Hyman DM, Borsu L, Arcila ME, Konner J, Reis-Filho JS, Greenberg RA, Robson ME, Turner NC. Clin Cancer Res 2017; 23:6708-6720. doi: 10.1158/1078-0432.CCR-17-0544

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People

Britta  Weigelt, PhD

Britta Weigelt, PhD

Director, Gynecology DMT Research Laboratory

  • Molecular geneticist Britta Weigelt studies the genomics of gynecologic cancers and the use of circulating cell-free DNA for disease monitoring and the identification of therapy resistance mechanisms.
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Members

Charles  W. Ashley, MD
Charles W. Ashley

GYN Oncology Fellow

Arnaud  Da Cruz Paula, PhD
Arnaud Da Cruz Paula

Postdoctoral Research Fellow

Kimberly Dessources
Kimberly Dessources

GYN Oncology Fellow

Jacqueline Feinberg
Jacqueline Feinberg

GYN Oncology Fellow

Olga T. Filippova
Olga T Filippova

GYN Oncology Fellow

Sushmita Gordhandas
Sushmita Gordhandas

GYN Oncology Fellow

Etta Hanlon
Etta Hanlon

Research Technician

Sarah Kim, MD
Sarah Kim

GYN Oncology Fellow

Beryl Manning-Geist
Beryl Manning-Geist

GYN Oncology Fellow

Ana Maroldi
Ana Maroldi

Research Technician

Kathryn Miller
Kathryn Miller

GYN Oncology Fellow

Lea Moukarzel, MD
Lea Moukarzel

GYN Oncology Fellow

Evan Smith, MD
Evan Smith

GYN Oncology Fellow

Michelle Wu
Michelle Wu

Research Project Associate

William A. Zammarrelli III
William A. Zammarrelli III

GYN Oncology Fellow

Lab Alumni
Anthe Stylianou , BSc
Anthe Stylianou

Research Technician

Lab Affilations

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