Memorial Hospital Research Laboratories
The Cameron Brennan Lab
My laboratory focuses on the genomic analysis of human and mouse gliomas and medulloblastomas. I am an integral in the NIH Cancer Genome Anatomy Project, one site of which is here at Memorial Sloan Kettering. I have identified several novel micro-deletions and translocations in glioma that produce protein fusions likely to contribute to the biology of these tumors and is characterizing several of these novel fusion proteins.
Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, Teruya-Feldstein J, Gerald WL, Ladanyi M, Pandolfi PP. Identification of DOK genes as lung tumor suppressors. Nat Genet., Feb. 2010. [Epub ahead of print]
Verhaak RGW, Hoadley K, Purdom E, Wang V, Qi Y, Wilkerson M, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O’Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Hidgson JGH, James D, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM and Hayes DN. The Cancer Genome Atlas Research Network. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1. Cancer Cell, Jan. 2010.
Cheng YW, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are two forms of aberrant IGF2 expression in colorectal cancer. Int J Cancer (Epub ahead of print), Dec. 2009.
Brennan C*, Momota H*, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. *Co-first authors; Co-corresponding. PLoS One 4(11), Nov. 2009.
Chitale D, Gong Y, Taylor B, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Venkatraman ES, Zakowski M, Rusch V, Pao W, Gerald W and Ladanyi M. An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene 28(31):2773-83, Aug 2009.
Cameron W. Brennan, MD
- Physician-scientist Cameron Brennan focuses on genomic analysis of human and mouse gliomas and medulloblastomas.
- MD, Cornell University Medical College