Human Oncology & Pathogenesis Program

The Christopher Klebanoff Lab

Research

Christopher A. Klebanoff
Christopher A. Klebanoff, MD
Assistant attending and member, IOS-HOPP, MSKCC

A form of cancer immunotherapy termed adoptive T cell transfer (ACT), in which a patient’s own T cells are engineered to recognize and attack cancer cells, can induce durable complete remissions in patients with advanced hematologic malignancies. By contrast, a similar approach has thus far failed to work in most patients with solid malignancies, the leading cause of adult cancer-related deaths. Two critical gaps in knowledge have limited the ability of ACT to be successfully applied to solid cancers: 1) understanding which antigens on the surface of cancer cells can be targeted by T cells that do not have the potential to cross- react with and injure normal tissues, and 2) insight into what factor(s) restrain the ability of transferred T cells to infiltrate, expand, and persist within a solid tumor mass. Using diverse techniques, including single-cell sequencing, biophysical measurements of T cell receptor (TCR) affinity, genetic engineering, and structural immunobiology, the Klebanoff laboratory seeks to address both factors currently limiting the application of ACT for advanced solid cancers.

Research Projects

The Christopher Klebanoff Lab

Publications

People

Christopher A. Klebanoff

Christopher A. Klebanoff, MD

Assistant attending and member, IOS-HOPP, MSKCC

  • Physician-scientist Christopher A. Klebanoff studies T cell immunobiology with an emphasis on adoptive T cell immunotherapy for the treatment of solid malignancies.
  • MD, Emory University School of Medicine
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Physician profile

Members

Lauren B. Banks

Medical Oncology Fellow

Smita Chandran
Smita Chandran

Senior Research Scientist

Inaki Etzeberria
Inaki Etzeberria

Research Fellow

Si Ning “Leslie” Fu
Si Ning “Leslie” Fu

Research Assistant

Christopher Bryce Johnson

Resident Physician Research Fellow

Fei Yi
Fei Yi

Research Fellow

Natalie Zimmerman
Natalie Zimmerman

Research Technician

Lab Alumni
Erica Brophy
Erica Brophy

Research Technician

Razan Eltilib
Razan Eltilib

Senior Research Technician

Matthew Femia
Matthew Femia

Research Technician

Patricia Lopez

Senior Research Technician

Lab Affilations

Achievements

  • NIH Fellows Award for Research Excellence (2013)
  • NCI/Center for Cancer Research Post Doctoral Research Fellow of the Year (2011)
  • AOA National Medical Honor Society (2006)
  • Howard Hughes Medical Institute continuing support scholarship (2004-2006)
  • Merk Index Award (2000)

Open Positions

Postdoctoral Fellows

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