Selected Publications
D Tylawsky, H Kiguchi, J Vaynshteyn, J Gerwin, J Shah, T. Islam, J Boyer, D Boué, M Snuderl, M Greenblatt, Y Shamay, P Raju, DA Heller*, “P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis. Nature Materials. 22,391-399 (2023).
Highlighted in: MSK News and Nature Materials News & Views
M Kim, C Chen, P Wang, JJ Mulvey, Y Yang, C Wun, M Antman-Passig, H-B Luo, S Cho, K Long-Roche, LV Ramanathan, A Jagota, M Zheng, Y Wang, DA Heller*. “Machine-Learning-Based Detection of an Ovarian Cancer Disease Fingerprint from Serum via Quantum Defect-Modified Carbon Nanotube Arrays.” Nature Biomedical Engineering (2022). https://www.mskcc.org/news/sensor-sniffs-cancer-using-artificial-intelligence
Z Yaari, Y Yang, E Apfelbaum, C Cupo, A Settle, Q Cullen, W Cai, K Long Roche, DA Levine, M Fleisher, L Ramanathan, M Zheng, A Jagota, DA Heller*. ”A Perception-Based Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers.” Science Advances 7 (2021) eabj0852. MSK News: https://www.mskcc.org/news/detect-ovarian-cancer-early-researchers-look-nanotechnology
J Budhathoki-Uprety, J Shah, JA Korsen, AE Wayne, TV Galassi, JR Cohen, JD Harvey, PV Jena, LV Ramanathan, EA Jaimes, DA Heller*. “Synthetic Molecular Recognition Nanosensor Paint for Microalbuminuria.” Nature Communications 10 (2019) 3605.
[MSK News: https://www.mskcc.org/news/science-meets-art-produce-diagnostic-test-us…]
TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680.
RM Williams, C Lee, TV Galassi, JD Harvey, R Leicher, M Sirenko, M Dorso, J Shah, N Olvera, F Dao, DA Levine,DA Heller*. “Non-Invasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant.” Science Advances 4 (2018) eaaq1090.
Y Shamay, J Shah, DF Tschaharganeh, D Roxbury, J Budhathoki-Uprety, M Işık, A Mizrachi, K Nawaly, JL Sugarman, E Baut, MR Neiman, DC Johnson, R Sridharan, KL Chu, VK Rajasekhar, JD Chodera, SW Lowe, DA Heller*, “Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines” Nature Materials 4 (2018) 361-368. [MSK News Link: https://www.mskcc.org/news/special-delivery-nano-size-particles-carry-p…]
Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano 11 (2017) 10689-1070. [WCM News Link: https://news.weill.cornell.edu/news/2017/09/nano-sensors-taste-fat-in-l…]
JD Harvey, PV Jena, HA Baker, GH Zerze, RM Williams, TV Galassi, D Roxbury, J Mittal, DA Heller: “A Carbon Nanotube Reporter of miRNA Hybridization Events In Vivo.” Nature Biomedical Engineering 1 (2017) 0041.
[MSK News Link: https://www.mskcc.org/news/detective-work-implantable-nanosensors-could…]
A Mizrachi, Y Shamay, J Shah, S Brook, J Soong, V Rajasekhar, J Humm, J Healey, S Powell, J Baselga, DA Heller*, A Haimovitz-Friedman*, M Scaltriti*: “Tumor-specific PI3K inhibition via nanoparticle delivery in head and neck squamous cell carcinoma.” Nature Communications 8 (2017) 14292.
[MSK News Link: https://www.mskcc.org/news/nanoparticles-help-drugs-target-head-and-nec…]
Y Shamay, M Elkabets, H Li, J Shah, S Brook, F Wang, K Adler, E Baut, M Scaltriti, PV Jena, EE Gardner, JT Poirier, CM Rudin, J Baselga, A Haimovitz-Friedman, DA Heller*: “P-selectin is a Nanotherapeutic Delivery Target to the Tumor Microenvironment.” Science Translational Medicine 8 (2016) 345ra8 [Highlighted in Science Translational Medicine 8 (2016) 374fs11, Nature Reviews Clinical Oncology (2016), and Cancer Discovery (2016).]
Full Publications List
(100) C Chen, Y Wu, S-T Wang, N Berisha, MT Manzari, K Vogt, O Gang, DA Heller*. “Fragment-Based Drug Nanoaggregation Reveals Drivers of Self-Assembly.” Nature Communications (2023) In press.
(99) M Kim, D Goerzen, PV Jena, JE Zeng, M Pasquali, RA Meidl, DA Heller*. “Human and Environmental Safety of Carbon Nanotubes Across their Life Cycle.” Nature Reviews Materials (2023) In press.
(98) M Antman-Passig, Z Yaari, D Goerzen, R Parikh, S Chatman, LE Komer, C Chen, E Grabarnik, M Mathieu, A Haimovitz-Friedman, DA Heller*. “Nanoreporter identifies lysosomal storage disease lipid accumulation intracranially.” Nano Letters (2023) In press.
(97) BE McLarney, M Kim, S Roberts, M Skubal, H-T Hsu, A Ogirala, E Pratt, N Pillarsetty, DA Heller, JS Lewis, J Grimm*. “Ambient Light–Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via pH Low-Insertion Peptide Conjugated to Indocyanine Green.” Journal of Nuclear Medicine 64 (2023) 1647-1653.
(96) J Islam, P Conroy, C Fercher, M Kim, Z Yaari, M Jones, TDM Bell, T Caradoc-Davies, R Law, J Whisstock, D Heller, S Mahler, S Corrie*. “Design of Polarity-Dependent Immunosensors Based on the Structural Analysis of Engineered Antibodies.” ACS Chemical Biology 18 (2023) 1863-1871.
(95) M Kim, M Panagiotakopoulou, C Chen, S Ruiz, K Ganesh, T Tammela, DA Heller*. “Micro-Engineering and Nano- Engineering Approaches to Investigate Tumour Ecosystems.” Nature Reviews Cancer 23 (2023) 581-599.
(94) M Kim, C Chen, ZA Yaari, R Frederiksen, E Randall, J Wollowitz, C Cupo, X Wu, J Shah, DW. Worroll, RE Langenbacher, D Goerzen, Y-M Li, H An, Y Wang, DA Heller*. “Nanosensor-Based Monitoring of Autophagy-Associated Lysosomal Acidification In Vivo.” Nature Chemical Biology (2023). https://doi.org/10.1038/s41589-023-01364-9
(93) RE Langenbacher, CP Horoszko, M Kim, DA Heller*. “Hematoxylin Nuclear Stain Reports Oxidative Stress Via Near-Infrared Emission.” ACS Chemical Biology 19 (2023) 1237-1245. PMCID: PMC10289833
(92) D Tylawsky, H Kiguchi, J Vaynshteyn, J Gerwin, J Shah, T Islam, M Snuderl, M Greenblatt, D Boué, Y Shamay, P Raju*, DA Heller* “P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis.” Nature Materials 22 (2023) 391-399.
(91) JM Kubala, KB Laursen, R Schreiner, RM Williams, JC van der Mijn, MJ Crowley, NP Mongan, DM Nanus, DA Heller, LJ Gudas*. ”NDUFA4L2 reduces mitochondrial function resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.” Cancer Biology & Therapy 24 (2022) 2170669.
(90) R Feiner, E Jones, M Antman-Passig, T Irie, N Berisha, H Oved, D Khan, L Witek, RM White, DA Heller*. “Drug-Eluting Rubber Bands for Tissue Ligation.” ACS Applied Materials & Interfaces 14 (2022) 27675-27685.
(89) M Antman-Passig, E Wong, GR Frost, C Cupo, J Shah, A Agustinus, Z Chen, C Mancinelli, M Kamel, T Li, LA Jonas, Y-M Li, DA Heller*. “Optical Nanosensor for Intracellular and Intracranial Detection of Amyloid-beta.” ACS Nano 16 (2022) 7269-7283.
(88) LN Benson, Y Liu, X Wang, Y Xiong, SW Rhee, Y Guo, KS Deck, CJ Mora, L-X Li, L Huang, JT Andrews, Z Qin, RS Hoover, B Ko, RM Williams, DA Heller, EA Jaimes, S Mu*. “The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension” Circulation R.
(87) M Kim, C Chen, P Wang, JJ Mulvey, Y Yang, C Wun, M Antman-Passig, H-B Luo, S Cho, K Long-Roche, LV Ramanathan, A Jagota, M Zheng, Y Wang, DA Heller*. “Machine-Learning-Based Detection of an Ovarian Cancer Disease Fingerprint from Serum via Quantum Defect-Modified Carbon Nanotube Arrays.” Nature Biomedical Engineering (2022). https://www.mskcc.org/news/sensor-sniffs-cancer-using-artificial-intelligence
(86) C Chen, Z Yaari, E Apfelbaum, P Grodzinski, Y Shamay, DA Heller*. “Merging Data Curation and Machine Learning to Improve Nanomedicines.” Advanced Drug Delivery Reviews (2022) 114172.
(85) PV Jena, M Gravely, CC Cupo, MM Safaee, D Roxbury*, DA Heller* “Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles.” ACS Nano (2022).
(84) RM Williams, J Shah, E Mercer, HS Tian, V Thompson, JM Cheung, M Dorso, JM Kubala, LJ Gudas, E de Stanchina, EA Jaimes,* DA Heller*. “Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin-Induced Acute Kidney Injury.” Frontiers in Pharmacology 12 (2021).
(83) X Guo, L Xu, H Velazquez, T-M Chen, R Williams, D Heller, B Burtness, R Safirstein, G Desir*. Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation. Journal of the American Society of Nephrology (2021).
(82) Z Yaari, Y Yang, E Apfelbaum, C Cupo, A Settle, Q Cullen, W Cai, K Long Roche, DA Levine, M Fleisher, L Ramanathan, M Zheng, A Jagota, DA Heller*. “A Perception-Based Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers.” Science Advances 7 (2021) eabj0852.
(81) CP Horoszko, PJ Schnatz, J Budhathoki-Uprety, RV Rao-Pothuraju, RL Koder, DA Heller*. “Non-Covalent Coatings on Carbon Nanotubes Mediate Photosensitizer Interactions.” ACS Applied Materials & Interfaces 13 (2021) 51343–51350.
(80) R Langenbacher, J Budhathoki-Uprety, PV Jena, D Roxbury, J Streit, M Zheng, DA Heller*. “Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes.” Nano Letters 21 (2021) 6441-6448. [PMID: 34296885]
(79) B Podlesny, B Olszewska, Z Yaari, PV Jena, G Ghahramani, R Feiner, DA Heller*, D Janas*. “En route to single-step, two-phase purification of carbon nanotubes facilitated by high-throughput spectroscopy.” Scientific Reports 11 (2021) 10618.
(78) MT Manzari, Y Shamay, H Kiguchi, M Scaltriti, N Rosen, DA Heller*. “Targeted Drug Delivery Strategies for Precision Medicines” Nature Reviews Materials (2021).PMID: 28867241
(77) RM Williams, S Chen, RE Langenbacher, TV Galassi, JD Harvey, PV Jena, J Budhathoki-Uprety*, M Luo*, DA Heller*. “Harnessing Nanotechnology to Expand the Toolbox of Chemical Biology” Nature Chemical Biology 17 (2021) 129-137. PMID: 33414556
(76) Z Yaari, JM Cheung, HA Baker, RS Frederiksen, PV Jena, F Jiao, S Scheuring, M Luo, DA Heller*. “Nanoreporter of an Enzymatic Suicide Inactivation Pathway” Nano Letters 20 (2020) 7819-7829. PMID: 33119310
(75) “Dual Inhibition of MCL1 and BCL2 in Lymphoma Using Tumor Targeted Nanoparticles for Drug Delivery” Blood (2020). PMID: 33067607
(74) RM Williams, JD Harvey, J Budhathoki-Uprety, DA Heller*. “A Glutathione-S-transferase Fusion Protein Nanosensor.” Nano Letters 20 (2020) 7287−7295. PMID: 32955895
(73) SJ Han, RM Williams, M Kim, DA Heller, V D’Agati, M Schmidt-Supprian, and HT Lee*. “Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury” JCI Insight 5 (2020) e139246. PMCID: PMC7566738
(72) TV Galassi, M Antman-Passig, Z Yaari, J Jessurun, RE Schwartz, DA Heller*. “Long-Term In Vivo Biocompatibility of Single-Walled Carbon Nanotubes.” PLoS One 15 (2020) e0226791. PMCID: PMC7202660
(71) M Ruscetti, JP Morris, R Mezzadra, J Russell, J Leibold, PB Romesser, J Simon, A Kulick, Y-j Ho, M Fennell, J Li, RJ Norgard, JE Wilkinson, D Alonso-Curbelo, R Sridharan, DA Heller, E de Stanchina, BZ Stanger, CJ Sherr, SW Lowe*. “Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.”Cell 181 (2020) 424-441. PMCID: PMC7872414
(70) SJ Han, RM Williams, V D’Agati, EA Jaimes, DA Heller, HT Lee*. “Selective Nanoparticle-Mediated Targeting of Renal Tubular Toll-Like Receptor 9 Attenuates Ischemic Acute Kidney Injury.” Kidney International 98 (2020) 76-87. PMCID: PMC7872414
(69) CP Horoszko, PV Jena, D Roxbury, SV. Rotkin, DA Heller*. “Optical Voltammetry of Polymer-Encapsulated Single-Walled Carbon Nanotubes.” Journal of Physical Chemistry C 123 (2019) 24200-24208. PMCID: PMC7371339
(68) MA Lee, CM Duarte, VM Eguíluz, DA Heller, R Langer, MG Meekan, HD Sikes, M Srivastava, MS Strano*, RP Wilson. “Can Fish and Cell Phones Teach Us About Our Health?” ACS Sensors 4 (2019) 2566-2570. PMID: 31576740
(67) J Budhathoki-Uprety, J Shah, JA Korsen, AE Wayne, TV Galassi, JR Cohen, JD Harvey, PV Jena, LV Ramanathan, EA Jaimes, DA Heller*. “Synthetic Molecular Recognition Nanosensor Paint for Microalbuminuria.” Nature Communications 10 (2019) 3605. [PMID: 31399600]
(66) H Kodama, Y Shamay, Y Kimura, J Shah, SB Solomon, D Heller, G Srimathveeravalli*. “Electroporation-induced changes in tumor vasculature and microenvironment can promote the delivery and increase the efficacy of sorafenib nanoparticles”. Bioelectrochemistry 130 (2019) 107328. [PMID: 31306879]
(65) JD Harvey, RM Williams, KM. Tully, HA Baker, Y Shamay, DA Heller*. “An in Vivo Nanosensor Measures Compartmental Doxorubicin Exposure.” Nano Letters (2019).
(64) JD Harvey, HA Baker, MV Ortiz, A Kentsis, DA Heller*. “HIV Detection via a Carbon Nanotube RNA Sensor.” ACS Sensors 4 (2019) 1236-1244.
(63) TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680.
(62) RM Williams, C Lee, DA Heller*. “A Fluorescent Carbon Nanotube Sensor Detects the Metastatic Prostate Cancer Biomarker uPA.” ACS Sensors 3 (2018) 1838–1845.
(61) JD Harvey, GH Zerze, KM Tully, J Mittal, DA Heller*. “Electrostatic Screening Modulates Analyte Binding and Emission of Carbon Nanotubes.” Journal of Physical Chemistry C (2018)
(60) RM Williams, C Lee, TV Galassi, JD Harvey, R Leicher, M Sirenko, M Dorso, J Shah, N Olvera, F Dao, DA Levine, DA Heller*. “Non-Invasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant.” Science Advances 4 (2018) eaaq1090.
(59) Y Shamay, J Shah, DF Tschaharganeh, D Roxbury, J Budhathoki-Uprety, M Işık, A Mizrachi, K Nawaly, JL Sugarman, E Baut, MR Neiman, DC Johnson, R Sridharan, KL Chu, VK Rajasekhar, JD Chodera, SW Lowe, DA Heller*, “Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines” Nature Materials (2018)
(58) RM Williams, J Shah, HS Tian, Xi Chen, F Geissman, EA Jaimes, DA Heller*, “Selective Nanoparticle Targeting of the Renal Tubules.” Hypertension 71 (2018) 87-94.
[Highlighted in Hypertension Perspective, Yap, et. al., 2017]
(57) JD Harvey, HA. Baker, E Mercer, J Budhathoki-Uprety, DA Heller*, “Control of carbon nanotube solvatochromic response to chemotherapeutic agents.” ACS Applied Materials & Interfaces 9 (2017) 37947-37953.
(56) Sims CM, Hanna SK, Heller DA, Horoszko CP, Johnson ME, Montoro Bustos AR, Reipa V, Riley KR, Nelson BC. Redox-active nanomaterials for nanomedicine applications. Nanoscale. 2017 Oct 19;9(40):15226-15251. doi: 10.1039/c7nr05429g. Review. [PMID: 28991962]
(55) Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano. 2017 Sep 12. doi: 10.1021/acsnano.7b04743. [Epub ahead of print] [PMID: 28898055]
(54) Harvey JD, Baker HA, Mercer E, Budhathoki-Uprety J, Heller DA. Control of Carbon Nanotube Solvatochromic Response to Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37947-37953. doi: 10.1021/acsami.7b12015. Epub 2017 Oct 19. [PMID: 29048868]
(53) Jena PV, Safaee MM, Heller DA, Roxbury D. DNA-Carbon Nanotube Complexation Affinity and Photoluminescence Modulation Are Independent. ACS Appl Mater Interfaces. 2017 Jun 28;9(25):21397-21405. doi: 10.1021/acsami.7b05678. Epub 2017 Jun 15. [PMID: 28573867]
(52) J Budhathoki-Uprety, RE Langenbacher, PV Jena, D Roxbury, DA Heller*: “A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway.” ACS Nano 11 (2017) 3875-3882.
(51) JD Harvey, PV Jena, HA Baker, GH Zerze, RM Williams, TV Galassi, D Roxbury, J Mittal, DA Heller: “A Carbon Nanotube Reporter of miRNA Hybridization Events In Vivo.” Nature Biomedical Engineering 1 (2017) 0041.
(50) A Mizrachi, Y Shamay, J Shah, S Brook, J Soong, V Rajasekhar, J Humm, J Healey, S Powell, J Baselga, DA Heller*, A Haimovitz-Friedman*, M Scaltriti*: “Tumor-specific PI3K inhibition via nanoparticle delivery in head and neck squamous cell carcinoma.” Nature Communications 8 (2017) 14292.
(49) DA Scheinberg*, J Grimm, DA Heller, EP Stater, M Bradbury, MR McDevitt: “Advances in the clinical translation of nanotechnology.” Current Opinion in Biotechnology 46 (2017) 66-73.
(48) PV Jena, TV Galassi, D Roxbury, DA Heller*: “Review—Progress toward Applications of Carbon Nanotube Photoluminescence.” ECS Journal of Solid State Science and Technology 6 (2017) M3075-M3077.
(47) TV Galassi, PV Jena, D Roxbury, DA Heller*: “Single nanotube spectral imaging to determine molar concentrations of isolated carbon nanotube species.” Analytical Chemistry 89 (2017) 1073-1077.
(46) Y Shamay, M Elkabets, H Li, J Shah, S Brook, F Wang, K Adler, E Baut, M Scaltriti, PV Jena, EE Gardner, JT Poirier, CM Rudin, J Baselga, A Haimovitz-Friedman, DA Heller*: “P-selectin is a Nanotherapeutic Delivery Target to the Tumor Microenvironment.” Science Translational Medicine 8 (2016) 345ra87. [Highlighted in Science Translational Medicine 8 (2016) 374fs11, Nature Reviews Clinical Oncology (2016), and Cancer Discovery (2016).]
(45) RM Williams, EA Jaimes*, DA Heller*: “Nanomedicines for Kidney Diseases.” Kidney International 90 (2016) 740-745.
(44) D Roxbury, PV Jena, Y Shamay, CP Horoszko, DA Heller*: “Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation.” ACS Nano 10 (2016) 499-506.
(43) PV Jena, Y Shamay, J Shah, D Roxbury, N Paknejad, DA Heller*: “Photoluminescent Carbon Nanotubes Interrogate the Permeability of Multicellular Tumor Spheroids.” Carbon 97 (2016) 99-109.
(42) D Roxbury, PV Jena, RM Williams, E Balazs, P Niethammer, S Marcet, M Verhaegen, S Blais-Ouellette, DA Heller*: “Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging.” Scientific Reports 5 (2015) 14167.
(41) RM Williams, J Shah, BD Ng, DR Minton, LJ Gudas, C Park, DA. Heller*: “Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium.” Nano Letters 15 (2015) 2358-2364.
(40) J Budhathoki-Uprety, PV Jena, D Roxbury, DA Heller*: “Helical Polycarbodiimide Cloaking of Carbon Nanotubes Enables Inter-Nanotube Exciton Energy Transfer Modulation.” Journal of the American Chemical Society 136 (2014) 15545-15550.
(38) JJ Mulvey, EN Feinberg, S Alidori, MR McDevitt, DA Heller, DA Scheinberg*: “Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes.” International Journal of Nanomedicine 9 (2014) 4245-4255.
(32) JW Kang, FT Nguyen, N Lue, RR Dasari, DA Heller*: “Measuring Uptake Dynamics of Multiple, Identifiable Carbon Nanotube Species via High-Speed Confocal Raman Imaging of Live Cells.” Nano Letters 12 (2012) 6170-6174.
Publications from work prior to MSKCC:
(39) J Zhang, S Kruss, AJ Hilmer, S Shimzu, Z Schmois, FDL Cruz, PW Barone, NF Reuel, DA Heller, MS Strano*: “A Rapid, Direct, Quantitative, and Label-Free Detector of Cardiac Biomarker Troponin T Using Near Infrared Fluorescent Single-walled Carbon Nanotube Sensors.” Advanced Healthcare Materials 3 (2014) 412-423.
(37) J Zhang, MP Landry, PW Barone, J-H Kim, S Lin, ZW Ulissi, D Lin, B Mu, AA Boghossian, AJ Hilmer, A Rwei, AC Hinckley, S Kruss, MA Shandell, N Nair, S Blake, F Sen, S Sen, RG Croy, D Li, K Yum, J-H Ahn, H Jin, DA Heller, JM Essigmann, D Blankschtein, MS Strano*: “Corona Phase Molecular Recognition Using Nanotube-Adsorbed Polymer Complexes.” Nature Nanotechnology 8 (2013) 959-968.
(36) Y Zhang, JM Pelet, DA Heller, J Wallas, BJ Joseph, Y Dong, D Chen, Z Gu, DG Anderson*: “Lipid-Modified Aminoglycoside Derivatives for in vivo siRNA Delivery.” Advanced Materials 25 (2013) 4641-4645.
(35) AA Boghossian, F Sen, BM Gibbons, S Sen, SM Faltermier, JP Giraldo, CT Zhang, J Zhang, DA Heller, MS Strano*: “Application of Nanoparticle Antioxidants to Enable Hyperstable Chloroplasts for Solar Energy Harvesting.” Advanced Energy Materials 3 (2013) 881-893.
(34) A Sharei, J Zoldan, A Adamo, WY Sim, N Cho, E Jackson, S Mao, S Schneider, M-J Han, A Lytton-Jean, PA Basto, S Jhunjhunwala, J Lee, DA Heller, JW Kang, GC Hartoularos, K-S Kim, DG Anderson, R Langer*, KF Jensen*: “A vector-free microfluidic platform for intracellular delivery.” Proceedings of the National Academy of Sciences 110 (2013) 2082-2087.
(33) DA Heller, Y Levi, JM Pelet, JC Doloff, J Wallas, GW Pratt, S Jiang, G Sahay, A Schroeder, JE Schroeder, Y Chyan, C Zurenko, W Querbes, M Manzano, DS Kohane, R Langer, DG Anderson*: “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25 (2013) 1449-1454. [Highlighted in Science 339 (2013) 374-375.]
(31) AA Kayani, K Khoshmanesh, TG Nguyen, G Kostovski, AF Chrimes, M Nasabi, D Heller, A Mitchell, K Kalantar-Zadeh*: “Dynamic manipulation of modes in an optical waveguide using dielecrophoresis.” Electrophoresis 33 (2012) 2075-2085.
(30) AJ Hilmer, TP McNicholas, S Lin, J Zhang QH Wang, JD Mendenhall, C Song, DA Heller, PW Barone, D Blankschtein, MS Strano*: “The Role of Adsorbed Surfactant in the Reaction of Aryl Diazonium Salts with Single-Walled Carbon Nanotubes.” Langmuir 28 (2012) 1309-1321.
(29) A Schroeder, DA Heller, MM Winslow, JE Dahlman, GW Pratt, R Langer*, T Jacks*, DG Anderson*: “Treating metastatic cancer with nanotechnology.” Nature Reviews Cancer 12 (2012) 39-50.
(28) AA Boghossian, J Zhang, PW Barone, NF Reuel, J-H Kim, DA Heller, J-H Ahn, AJ Hilmer, A Rwei, JR Arkalgud, CT Zhang, MS Strano*: “Near-Infrared Fluorescent Sensors based on Single-Walled Carbon Nanotubes for Life Sciences Applications.” ChemSusChem 4 (2011) 848-863.
(27) DA Heller, GW Pratt, J Zhang, N Nair, AJ Hansborough, AA Boghossian, NF Reuel, PW Barone, MS Strano*: “Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics.” Proceedings of the National Academy of Sciences 108 (2011) 8544-8549.
(26) J Zhang, AA Boghossian, PW Barone, A Rwei, J-H Kim, D Lin, DA Heller, AJ Hilmer, N Nair, NF Reuel, MS Strano*. “Single Molecule Detection of Nitric Oxide Enabled by d(AT)15 DNA Adsorbed to Near Infrared Fluorescent Single-Walled Carbon Nanotubes.” Journal of the American Chemical Society 133 (2010) 567-581.
(25) J-H Han, GLC Paulus, R Maruyama, DA Heller, W-J Kim, PW Barone, CY Lee, JH Choi, M-H Ham, C Song, C Fantini, MS Strano*. “Exciton antennas and concentrators from core–shell and corrugated carbon nanotube filaments of homogeneous composition.” Nature Materials 9 (2010) 833-839.
(24) M-H Ham, JH Choi, AA Boghossian, ES Jeng, RA Graff, DA Heller, AC Chang, A Mattis, TH Bayburt, YV Grinkova, AS Zeiger, KJ Van Vliet, EK Hobbie, SG Sligar, CA Wraight, MS Strano*: “Photoelectrochemical complexes for solar energy conversion that chemically and autonomously regenerate.” Nature Chemistry 2 (2010) 929-936.
(23) H Jin, DA Heller, M Kalbacova, J-H Kim, J Zhang, AA Boghossian, N Maheshri, MS Strano*: “Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes.” Nature Nanotechnology 5 (2010) 302-309.
(22) J-H Kim, J-H Ahn, PW Barone, H Jin, J Zhang, DA Heller, MS Strano*: “A Luciferase/Single-Walled Carbon Nanotube Conjugate for Near-Infrared Fluorescent Detection of Cellular ATP.” Angewandte Chemie 49 (2010) 1456-1459.
(21) J-H Kim, DA Heller, H Jin, PW Barone, C Song, J Zhang, LJ Trudel, GN Wogan, SR Tannenbaum, MS Strano*: “The rational design of nitric oxide selectivity in single-walled carbon nanotube near-infrared fluorescence sensors for biological detection.” Nature Chemistry 1 (2009) 473-481.
(20) DA Heller, H Jin, BM Martinez, D Patel, BM Miller, T-K Yeung, PV Jena, C Höbartner, T Ha, SK Silverman, MS Strano*: “Multi-modal optical sensing and analyte specificity via single-walled carbon nanotubes.” Nature Nanotechnology 4 (2009) 114-120.
(19) H Jin, DA Heller, R Sharma, MS Strano*: “Size-Dependent Cellular Uptake and Expulsion of Single-Walled Carbon Nanotubes: Single Particle Tracking and a Generic Uptake Model for Nanoparticles.” ACS Nano 3 (2009) 149-158.
(18) MS Strano, AA Boghossian, W-J Kim, PW Barone, ES Jeng, DA Heller, N Nair, H Jin, R Sharma, CY Lee: “The Chemistry of Single-Walled Nanotubes.” MRS Bulletin 34 (2009) 950-961.
(17) H Jin, DA Heller, J-H Kim, MS Strano*: “A Stochastic Analysis of Stepwise Fluorescence Quenching Reactions on Single-Walled Carbon Nanotubes.” Nano Letters 8 (2008) 4299-4304.
(16) H Jin, DA Heller, MS Strano*: “Single-Particle Tracking of Endocytosis and Exocytosis of Single-Walled Carbon Nanotubes in NIH-3T3 Cells.” Nano Letters 8 (2008) 1577-1585.
(15) A Rajan, MS Strano, DA Heller, T Hertel, K Schulten*: “Length-Dependent Optical Effects in Single Walled Carbon Nanotubes.” Journal of Physical Chemistry B 112 (2008) 6211-6213.
(14) H Jin, ES Jeng, DA Heller, PV Jena, R Kirmse, J Langowski, MS Strano*: “Divalent Ion and Thermally Induced DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes.” Macromolecules 40 (2007) 6731-6739.
(13) JH Choi, FT Nguyen, PW Barone, DA Heller, AE Moll, D Patel, SA Boppart, MS Strano*: “Multimodal Biomedical Imaging with Asymmetric Single-Walled Carbon Nanotube/Iron Oxide Nanoparticle Complexes.” Nano Letters 7 (2007) 861-867.
(12) DA Heller, ES Jeng, T Yeung, BM Martinez, AE Moll, JB Gastala, MS Strano*: “Optical Detection of DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes.” Science 311 (2006) 508-511.
(11) A Jorio, C. Fantini, MA Pimenta, DA Heller, MS Strano, MS Dresselhaus, Y Oyama, J Jiang, R Saito*: “Carbon nanotube population analysis from Raman and photoluminescence intensities.” Applied Physics Letters 88 (2006) 023109s.
(10) DA Heller, S Baik, TE Eurell, MS Strano*: “Single-Walled Carbon Nanotube Spectroscopy in Live Cells: Towards Long-Term Labels and Optical Sensors.” Advanced Materials 17 (2005) 2793-2799.
(9) EK Lewis, WC Haaland, FT Nguyen, DA Heller, MJ Allen, RR MacGregor, CS Berger, B Willingham, LA Burns, GBI Scott, C Kittrell, BR Johnson, RF Curl, ML Metzker*: “Color-Blind Fluorescence Detection for Four-Color DNA Sequencing.” Proceedings of the National Academy of Sciences 102 (2005) 5346-5351.
(8) RA Graff, JP Swanson, PW Barone, S Baik, DA Heller, MS Strano: “Achieving Individual Nanotube Dispersion at High Loading in Single-Walled Carbon Nanotube Composites.” Advanced Materials 17 (2005) 980-984.
(7) DA Heller, PW Barone, MS Strano*: “Sonication-induced changes in chiral distribution: A complication to the use of single-walled carbon nanotube fluorescence for determining species distribution.” Carbon 43 (2005) 651-653.
(6) PW Barone, S Baik, DA Heller, MS Strano*: “Near-infrared optical sensors based on single-walled carbon nanotubes.” Nature Materials 4 (2005) 86-92.
(5) DA Heller, V Garga, KJ Kelleher, T-C Lee, S Mahbubani, LA Sigworth, TR Lee*, MA Rea*: “Patterned networks of mouse hippocampal neurons on peptide-coated gold surfaces.” Biomaterials 26 (2005) 883-889.
(4) DA Heller, RM Mayrhofer, S Baik, YV Grinkova, ML Usrey, MS Strano*: “Concomitant length and diameter separation of single-walled carbon nanotubes.” Journal of the American Chemical Society 126 (2004) 14567-14573.
(3) DA Heller, PW Barone, JP Swanson, RM Mayrhofer, MS Strano*: “Using Raman spectroscopy to elucidate the aggregation state of single-walled carbon nanotubes.” Journal of Physical Chemistry B 108 (2004) 6905-6909.
(2) MS Strano*, M Zheng, A Jagota, GB Onoa, DA Heller, PW Barone, ML Usrey: “Understanding the nature of the DNA-assisted separation of single-walled carbon nanotubes using fluorescence and Raman spectroscopy.” Nano Letters 4 (2004) 543-550.
(1) SK Doorn, DA Heller, PW Barone, ML Usrey, MS Strano*: “Resonant Raman excitation profiles of individually dispersed single walled carbon nanotubes in solution.” Applied Physics A-Materials Science & Processing 78 (2004) 1147-55.