Lengel HB, Mastrogiacomo B, Connolly JG, Tan KS, Liu Y, Fick CN, Dunne EG, He D, Lankadasari MB, Satravada BA, Sun Y, Kundra R, Fong C, Smith S, Riely GF, Rudin CM, Gomez DR, Solit DB, Berger MF, Li BT, Mayo MW, Matei I, Lyden DC, Adusumilli PS, Schultz N, Sanchez-Vega F, Jones DR. Genomic mapping of metastatic organotropism in lung adenocarcinoma. Cancer Cell 2023;S1535-6108(23)00091-0. doi: 10.1016/j.ccell.2023.03.018. Online ahead of print.

Karasaki T, Moore DA, Veeriah S, Lombardelli CN, Toncheva A , Magno N, Ward S, Al Bakir M, Watkins TBK, Grigoriadis K, Huebner A, Hill MS, Frankell AM, Gimeno-Valiente F, Saghafinia S, Kanu N, Dietzen M, Pich O, Lim E, Martinez-Ruiz C, Black JRM, Puttick C, Biswas D, Lee C, Colliver E, Enfield KSS, Hessey S, Abbosh C, Hiley CT, Zaccaria S, Litchfield K, Birkbak NJ, Cadieux EL, Demeulemeester J, Van Loo P, Sanchez-Vega F, Jones DR, Rekhtman N, Travis WD, Hackshaw A, Marafioti T, Salgado R, Le Quesne J, Nicholson AG, McGranahan N, Swanton C, Hanjani MJ. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nat Med 2023;29(4):833-845.

Morris BB, Smith JP, Zhang Q, Jiang Z, Hampton OA, Churchman ML, Arnold SM, Owen DH, Gray JE, Dillon PM, Soliman HH, Stover DG, Colman H, Chakravarti A, Shain KH, Silva AS, Villano JL, Vogelbaum MA, Borges VF, Akerley WL, Gentzler RD, Hall RD, Matsen CB, Ulrich CM, Post AR, Nix DA, Singer EA, Larner JM, Stukenberg PT, Jones DR, Mayo MW. Replicative Instability Drives Cancer Progression. Biomolecules 2022;12(11):1570.

Jee J, Lebow ES, Namakydoust A, Paik PK, Chaft JE, Jayakumaran G, Brannon AR, Benayed R, Zehir A, Donoghue M, Schultz N, Chakravarty D, Kundra R, Madupuri R, Farag J, Murciano-Goroff YR, Tu HY, Xu CR, Martinez A, Wilhem C,  Galle J, Daly B, Yu HA, Offin M, Hellmann MD, Lito P, Arbour KC, Zauderer MG, Kris MG, Ng KK, Eng J, Preeshagul I, Lai WV, Fiore JJ, Iqbal A, Molena D, Rocco G, Park BJ, Lim LP, Li M, De Silva M, Chan DL, Diakos CI, Itchins M, Clarke S, Pavlakis N, Lee A, Rekhtman N, Chang J, Travis WD, Riely GJ, Solit DB, Arcila ME, Ladanyi M, Gonen M, Rusch VW, Rimner A, Gomez D, Drilon A, Scher HI, Shah SP, Berger MF, Diaz Jr LA, Shen R, Razavi P, Reis-Filho JS, Jones DR, Rudin CM, Isbell JM, Li BT. Overall survival with circulating tumor DNA-guided therapy in advanced non-small cell lung cancer. Nat Med 2022;28:2353–63.

Liu Y, Chudgar N, Mastrogiacomo B, He D, Lankadasari MB, Bapat S, Jones GD, Sanchez-Vega F, Tan KS, Schultz N, Mukherjee S, Offit K, Bao Y, Bott MJ, Rekhtman N, Adusumilli PS, Li BT, Mayo MW, Jones DR. A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos. Sci Transl Med 2022;14(665):eabo1050.

Mukherjee S, Bandlamudi C, Hellmann MD, Kemel Y, Rizvi H, Tkachuk K, Khurram A, Walsh M, Zauderer M, Mandelker D, Topka S, Zehir A, Srinivasan P, Selvan ME, Carlo MI,  Cadoo K, Liu Y, Lipkin SM, Belhadj S, Gumus Z, Klein R, Ladanyi M, Solit D, Robson M, Jones DR, Kris MG , Vijai J, Stadler Z, Amos C, Taylor BS, Berger MF, Rudin C, Offit K. Germline pathogenic variants impact clinicopathology of advanced lung cancer.  Cancer Epidemiol Biomarkers Prev 2022;31(7):1450-1459.

Nguyen B, Fong C, Luthra A, Smith SA, DiNatale RG, Nandakumar S, Walch H, Chatila WK, Madupuri R, Kundra R, Bielski CM, Mastrogiacomo B, Donoghue MTA, Boire A, Chandarlapaty S, Ganesh K, Harding JJ, Iacobuzio-Donahue CA, Razavi P, Reznik E, Rudin CM, Zamarin D, Abida W, Abou-Alfa GK, Aghajanian C, Cercek A, Chi P, Feldman D, Ho AL, Iyer G, Janjigian YY, Morris M, Motzer RJ, O’Reilly EM, Postow MA, Raj NP, Riely GJ, Robson ME, Rosenberg JE, Safonov A, Shoushtari AN, Tap W, Teo MY, Varghese AM, Voss M, Yaeger R, Zauderer MG, Abu-Rustum N, Garcia-Aguilar J, Bochner B, Hakimi A, Jarnagin WR, Jones DR, Molena D, Morris L, Rios-Doria E, Russo P, Singer S, Strong VE, Chakravarty D, Ellenson LH, Gopalan A, Reis-Filho JS, Weigelt B, Ladanyi M, Gonen M, Shah SP, Massague J, Gao J, Zehir A, Berger MF, Solit DB, Bakhoum SF, Sanchez-Vega F, Schultz N. Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell 2022;185(3):563-575.e11.

Chan JM, Quintanal-Villalonga A, Gao V, Xie Y, Viola Allaj V, Chaudhary O, Yarlagadda VK, Masilionis I, Egger J, Mattar M, Chow A, Wang JL, Offin MD, Ciampricotti M, Bhanot UK, Walle T, Lai WV, Bott MJ, Jones DR, Hollmann T, Poirier JT, Nawy T, Mazutis L, Sen T, Pe’er D, Rudin CM. Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer Cell 2021;39:1479-96.

Lengel HB, Connolly JG, Jones GD, Caso R, Zhou J, Sanchez-Vega F, Mastrogiacomo B, Isbell JM, Li BT, Liu Y, Rekhtman N, Jones DR. The emerging importance of tumor genomics in operable non-small cell lung cancer. Cancers 2021;13(15):3656.

Jones GD, Brandt WS, Shen R, Sanchez-Vega F, Tan KS, Martin A, Zhou J, Berger M, Solit DB, Schultz N, Rizvi H, Liu Y, Adamski A, Chaft JE, Riely GJ, Rocco G, Bott MJ, Molena D, Ladanyi M, Travis WD, Rekhtman N, Park BJ, Adusumilli PS, Lyden D, Imielinski M, Mayo MW, Li BT, Jones DR. A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma. JAMA Surg. 2021;156(2):e205601.

Morris BB, Wages NA, Grant PA, Stukenberg PT, Gentzler RD, Hall RD, Akerley WL, Varghese TK, Arnold SM, Williams TM, Coppola V, Jones DR, Auble DT and Mayo MW. MYBL2-driven transcriptional programs link replication stress and error-prone DNA repair with genomic instability in lung adenocarcinoma. Front Oncol 2021 10:585551. doi: 10.3389/fonc.2020.585551.

Bojmar L, Kim HS, Tobias GC, Vatter FAP, Lucotti S, Gyan KE, Kenific CM,  Wan Z, Pascual V, Heaton TE, La Quaglia MP, Kelsen D, Trippett TM, Jones DR, Jarnagin WR, Matei IR, Zhang H, Hoshino A, Lyden D. Extracellular vesicle and particle isolation from cell lines, tissues and bodily fluids. STAR Protoc 2020;2(1):100225. doi: 10.1016/j.xpro.2020.100225.

Caso R, Sanchez-Vega F, Tan KS, Mastrogiacomo B, Zhou J, Jones GD, Nguyen B, Schultz N, Connolly JG, Brandt WS, Bott MJ, Rocco G, Molena D, Isbell JM, Liu Y, Mayo MW, Adusumilli PS, Travis WD, Jones DR. The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma. J Thorac Oncol 2020;15(12):1844-1856.

Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsworth MA, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia BA, O’Reilly EM, Kelsen D, Trippett TM, Jones DR, Matei IR, Jarnagin WR, Lyden D. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell 2020;182(4):1044-1061.e18.

Rodrigues G, Hoshino A, Matei IR, Scandariato I, Kenific CM, Kim HS, Casanova-Salas I, Dai D, Badwe CR, Gril B, Mark MT, Dill BD, Molina H, Benito-Martin A, Bojmar L, Offer K, LaPlant Q, Ararso Y, Buehring W, Wang H, Jiang X, Liu Y, Sabari JK, Shin SJ, Narula N, Rajasekhar VK, Zhang H, Costa Silva B, Rafii S, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, Pisapia D, de Sousa M, Lyden D. Tumour exosomal KIAA1199 protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol 2019;21:1403-12.  

Szymura SJ, Zaemes JP, Allison DF, Clift SH, D’Innocenzi JM, Gray LG, Mckenna BD, morris BB, Bekiranov S, LeGallo RD, Jones DR, Mayo MW. NF-ĸB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small clell lung cancer. Cell Commun Signal 2019;17(1):24.

Forde PM, Chaft JE, Smith KN, Anagnostou V, TCottrell TR, Hellmann MD, Yang SC, Jones DR, Broderick SR, Battafarano R, Rekhtman N, Olah Z, Naidoo J, Marrone KA, Verde F, Guo H, Caushi J, Chan HY, Scharpf RB, White J, Gabrielson E, Zahurak M, Rosner G, Rusch V, Wolchok JD, Merghoub T, Taube JM, Velculescu VE, Topalian SL, Brahmer JR, Pardoll DM. Neoadjuvant PD-1 blockade in resectable lung cancer. N Engl J Med 2018;378:1976-86.

Cottrell TR, Stein JE, Chaft JE, Thompson ED, Rekhtman N, Anagnostou V, Smith KN, Duffield AS, Anders RA, Isbell JM, Jones DR, Cuda JD, Battafarano R, Yang SC, Illei PB, Gabrielson E, Askin F, Velez M, Hellmann MD, Sauter JL, Danilova L, Velculescu VE, Wolchok JD, Topalian SL, Brahmer J, Pardoll DM, Cimino-Matthews A, Forde PM, Taube JM. Histopathologic features of response to neoadjuvant anti-PD-1 in resected non-small cell lung carcinomas (NSCLC):  a proposal for quantitative immune-related pathologic response criteria (irPRC). Ann Oncol 2018;29(8):1853-1860.

Bucciarelli PR, Tan KS, Chudgar NP, Brandt W, Montecalvo J, Eguchi T, Liu Y, Travis WD, Adusumilli PS, Jones DR. BRMS1 expression in surgically resected lung adenocarcinoma predicts future metastases and is associated with a poor prognosis. J Thorac Oncol 2018;13:73-84.

Amin EM, Liu Y, Deng S, Chudgar N, Mayo MW, Tan KS, Sanchez-Vega F, Schultz ND, Adusumilli PS, Jones DR. ADAR promotes lung adenocarcinoma migration and invasion through stabilization of FAK. Sci Signal 2017;10:497.

Kumar P, Dillon L, Shibata Y, Jazaeri A, Jones DR, Dutta A. Extrachromosomal circular DNA is released from normal tissues and cancers into the circulation. Mol Cancer Res 2017;15:1197-205.

Kadota K, Sima CS, Arcila ME, Hedvat C, Kris MG, Jones DR, Adusumilli PS, Travis WD. KRAS mutation is a significant prognostic factor in early-stage lung adenocarcinoma. Am J Surg Pathol 2016;40:1579-90.

Liu Y, Amin EB, Mayo MW, Chudgar NP, Bucciarelli PR, Kadota K, Adusumilli PS, Jones DR. CK2α’ drives lung cancer metastasis by targeting BRMS1 nuclear export and degradation. Cancer Res 2016;76:2675-86.

Liu Y, Mayo MW, Xiao A, Shock LS, Hall EH, Adusumilli PS, Jones DR. Loss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1.  Mol Cell Biol 2015;35(1):303-17.

Hall EH, Xiao A, Liu Y, Shock L, Brautigan DL, Mayo MW, Adusumilli PS, Jones DR. Breast cancer metastasis suppressor 1 inhibits cell migration and preserves an epithelial phenotype in human lung cells that express oncogenic K-RasV12 and loss of p53. PLoS One 2014 9(4) e95869.

Cieslik M, Stephen SA, Baranova N, Chodaparambil S, Kumar M, Allison D, Xu X, J Jacob Wamsley JJ, Gray LG, Jones DR, Mayo MW, Bekiranov S. Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition. Epigenet Chromatin 2013;6(1):28.

Kumar M, Allison DF, Baranova NN, Wamsley JJ, Szymura SJ, Katz AJ, Bekiranov S, Jones DR, Mayo MW. NF-B regulates the generation of non-small cell lung cancer initiating cells. PLoS One 2013; 8:e68597.

Liu Y, Mayo MW, Nagji AS, Allred EH, Shock LS, Xiao A, Stelow EB, Jones DR. BRMS1 suppresses lung cancer metastases through a novel E3 ligase function on histone acetyltransferase p300. Cancer Res 2013;73:1308-17.

Allison DF, Wamsley JJ, Kumar M, Li D, Gray LG, Udeshi ND, Hart GW, Jones DR, Hunt DF, Mayo MW. Modification of RelA by O-linked N-Acetylglucosamine links glucose metabolism to NF-B acetylation and transcription. Proc Natl Acad Sci 2012;109:16888-93.

Jones DR, Moskaluk CA, Gillenwater HH, Petroni GR, Burks SG, Philips J, et al. Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small cell lung cancer. J Thorac Oncol 2012;7:1683-90.

Marozkina NV, Wei C, Yemen S, Wallrabe H, Nagji AS, Liu L, Morozkina T, Jones DR, Gaston B. S-nitrosoglutathione reductase in human lung cancer. Am J Resp Cell Mol Biol 2012;46:63-70.

Liu Y, Mayo MW, Nagji AS, Smith PW, Ramsey CS, Li D, Jones DR. Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1. Oncogene 2012;31:1143-54.

Nagji AS, Cho SH, Liu Y, Lee JK, Jones DR. Multi-gene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer. Mol Cancer Ther 2010;9:2834-43.

Nagji AS, Liu Y, Stelow EB, Stukenborg GJ, Jones DR. BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathologic stage in non-small cell lung cancer. J Pathol 2010;221:229-37.

Smith PW, Liu Y, Siefert SA, Petroni GR, Moskaluk CA, Jones DR. Breast Cancer Metastasis Suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. Cancer Letters 2009;276:196-203.

Liu Y, Smith PW, Jones DR. Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing HDAC-1 mediated deacetylation of RelA/p65 and promoting apoptosis. Mol Cell Biol 2006;26:8683-96.