Memorial Hospital Research Laboratories
The James Young Lab
Our lab studies human dendritic cells, which are critical to the onset of cellular immunity. Dendritic cells also provide an important link between innate and adaptive immune responses. Our work is broadly informed by issues in clinical transplantation and tumor immunology.
Ratzinger G, Baggers J, de Cos MA, Yuan J, Reagan JL, Dao T, Munz C, Heller G, Young JW. Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells. J Immunol. 2004;173:2780-2791.
Munz C, Dao T, Ferlazzo G, de Cos MA, Goodman K, Young JW. Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells. Blood. 2005 Jan 1;105(1):266-73.
Boruchov AM, Heller G, Veri M-C, Bonvini E, Ravetch JV, Young JW. Activating and inhibitory IgG Fc receptors mediate opposing functions on human dendritic cells. J.Clin.Invest. 2005, 115: 2914-2923 (see also J.Clin.Invest. 2005, 115: 2585)
Yuan J, Latouche J-B, Hodges J, Houghton AN, Heller G, Sadelain M, Riviere I, Young JW. Langerhans-type dendritic cells genetically modified to express full-length antigen optimally stimulate CTLs in a CD4-dependent manner. J.Immunol. 2006, 176: 2357-2365.
James W. Young, MD
- Physician-scientist James Young studies innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.
- MD, Vanderbilt University