Human Oncology & Pathogenesis Program

The Omar Abdel-Wahab Lab

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Research

Omar Abdel-Wahab, MD
Edward P. Evans Chair in MDS, Director, MSK Center for Hematologic Malignancies, Member, Human Oncology and Pathogenesis Program & Leukemia Service

Omar Abdel-Wahab is a Member in Human Oncology and Pathogenesis Program (HOPP), an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center, and the Director of Memorial Sloan Kettering’s Center for Hematologic Malignancies. Dr. Abdel-Wahab’s research focuses on the role of genomic alterations in the pathogenesis of hematopoietic malignancies.

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The Omar Abdel-Wahab Lab

Featured News

In the Lab
Physician-scientist Omar Abdel-Wahab
Research Suggests How Boosting Neoantigens Can Make Immunotherapy More Effective

In mice, drugs that change the way proteins are assembled appear to make checkpoint inhibitor drugs work better.
In the Lab
Sloan Kettering Institute molecular biologist Christine Mayr
Scientists Find Cancer Drivers Hiding in a New Place

New findings from researchers at the Sloan Kettering Institute suggest that cancer causes may be lurking in the molecule that bridges DNA and protein.
In the Lab
MSK physician-scientist Omar Abdel-Wahab
Splicing May Be an Effective Target in the Fight against Cancer

New drugs are being developed that target part of the process to make proteins.

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Publications

North K, Benbarche S, Liu B, Pangallo J, Chen S, Stahl M, Bewersdorf JP, Stanley RF, Erickson C, Cho H, Pineda JMB, Thomas JD, Polaski JT, Belleville AE, Gabel AM, Udy DB, Humbert O, Kiem HP, Abdel-Wahab O (co-corresponding), Bradley RK (co-corresponding). Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. Nat Biotechnol. 2022 Mar 3. doi: 10.1038/s41587-022-01224-2. Epub ahead of print.

Wang E, Mi X, Thompson MC, Montoya S, Notti RQ, Afaghani J, Durham BH, Penson A, Witkowski MT, Lu SX, Bourcier J, Hogg SJ, Erickson C, Cui D, Cho H, Singer M, Totiger TM, Chaudhry S, Geyer M, Alencar A, Linley AJ, Palomba ML, Coombs CC, Park JH, Zelenetz A, Roeker L, Rosendahl M, Tsai DE, Ebata K, Brandhuber B, Hyman DM, Aifantis I, Mato A, Taylor J, Abdel-Wahab O. Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors. N Engl J Med. 2022 Feb 24;386(8):735-743. doi: 10.1056/NEJMoa2114110.

Lu SX, De Neef E, Thomas JD, Sabio E, Rousseau B, Gigoux M, Knorr DA, Greenbaum B, Elhanati Y, Hogg SJ, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham BH, Shah H, Chowell D, Gabel AM, Shen Y, Liu J, Jin J, Rhodes MC, Taylor RE, Molina H, Wolchok JD, Merghoub T, Diaz LA Jr, Abdel-Wahab O (co-corresponding; Lead Contact), Bradley RK (co-corresponding). Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021 Jun 18:S0092-8674(21)00690-5. doi: 10.1016/j.cell.2021.05.038. Epub ahead of print.

Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 Apr 12. doi: 10.1038/s41588-021-00828-9. Epub ahead of print.

Taylor J, Donoghue MT, Ho C, Petrova-Drus K, Al-Ahmadie HA, Funt SA, Zhang Y, Aypar U, Rao P, Chavan SS, Haddadin M, Tamari R, Giralt S, Tallman MS, Rampal RK, Baez P, Kappagantula R, Kosuri S, Dogan A, Tickoo SK, Reuter VE, Bosl GJ, Iacobuzio-Donahue CA, Solit DB, Taylor BS, Feldman DR, Abdel-Wahab O. Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor. J Clin Invest. 2020 Dec 1;130(12):6668-6676. doi: 10.1172/JCI139682. PMCID: PMC7685753.

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People

Pictured: Dr. Abdel-Wahab

Omar Abdel-Wahab, MD

Edward P. Evans Chair in MDS, Director, MSK Center for Hematologic Malignancies, Member, Human Oncology and Pathogenesis Program & Leukemia Service

  • Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.
  • MD, Duke University School of Medicine
[email protected]
Email Address
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Physician profile

Members

Salima Benbarche
Salima Benbarche

Research Scholar

Jessie Bourcier
Jessie Bourcier

Research Fellow

Sisi Chen
Sisi Chen

Research Scholar

Ha Na Cho, Research Assistant
Hana Cho

Research Assistant

Benjamin Durham, Instructor (Pathology)
Benjamin Durham

Instructor (Pathology)

Caroline Erickson
Caroline Erickson

Research Technician

Nina Fox
Nina Fox

Research Technician

Simon Hogg
Simon Hogg

Research Fellow

Won Kim

Graduate Student

Katherine Knorr
Katherine Knorr

Fellow

Bo Liu, Research Associate
Bo Liu

Research Associate

Bin Lu, Research Associate
Bin Lu

Research Associate

Danielle Richards
Danielle Richards

Program Assistant

Erich Sabio

Senior Research Scientist

Michael Singer
Michael Singer

Research Technician

Robert Stanley
Robert Stanley

Fellow

Steven Tittley
Steven Tittley

Senior Research Assistant

Eric Wang
Eric Wang

Research Scholar

Lab Alumni
Jihae Ahn
Jihae Ahn

Volunteer

Shlomzion Aumann
Shlomzion Aumann

Research Fellow

Lillian Bitner, Research Technician
Lillian Bitner

Research Technician

Young Rock Chung
Young Rock Chung

Research Technician

Daniel Cui
Daniel Cui

Research Technician

Luisa Escobar Hoyos

Research Fellow

Monisha Hosier
Monisha Hosier

Administrative Assistant II

Daichi Inoue, Visiting Investigator
Daichi Inoue

Visiting Investigator

Michelle Ki
Michelle Ki

Research Technician

Eunhee Kim
Eunhee Kim

Research Fellow

Min Kim
Min Kim

Research Technician

Pictured: Stanley Lee
Stanley Lee

Research Associate

Sydney Lu, Research Fellow
Sydney Lu

Assistant Member, Myeloma Service

Jean Baptiste Micol
Jean Baptiste Micol

Research Fellow

Alessandro Pastore, Senior Research Scientist
Alessandro Pastore

Senior Research Scientist

Alexander Penson, PhD
Alexander Penson

Senior Computational Biologist

Ruth Saganty
Ruth Saganty
Justin Taylor

Instructor (Dept. of Medicine)

Akihide Yoshimi, Senior Research Scientist
Akihide Yoshimi

Senior Research Scientist

Xiao Zhang
Lab Affiliations

Achievements

  • Josie Robertson Investigator (2012-2017)
  • Seldin-Smith Award for Pioneering Research, American Society of Clinical Investigation
  • Pershing Square Sohn Prize for Young Investigators in Cancer Research
  • Leukemia & Lymphoma Society Clinical Scholar Award
  • Joanne Levy Memorial Award for Outstanding Achievement, American Society of Hematology
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  • V Scholar Award, V Foundation
  • Junior Faculty Scholar Award, American Society of Hematology (ASH)
  • Damon Runyon Clinical Investigator Award

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Omar Abdel-Wahab discloses the following relationships and financial interests:

  • AIchemy, Inc.
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Envisagenics
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Epizyme
    Intellectual Property Rights
  • Janssen Global Services, LLC
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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