Memorial Hospital Research Laboratories

The Ying-Xian Pan Lab

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Research

Ying-Xian Pan
Ying-Xian Pan, MD, PhD

Physician-scientist Ying-Xian Pan studies the mechanisms of opioid actions, providing the foundation of developing novel drugs for pain treatment. 

The mu opioid receptors mediate the actions of morphine and most clinical analgesics, as well as drugs of abuse such as heroin. The goal of our research is to understand the mechanisms and functions of mu opioid receptor gene, OPRM1, gain insights into the pharmacological and physiological significance of the mechanisms and functions, and provide potential targets for developing novel drugs in control of pain and drug of abuse. 

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Publications

Le Rouzic V, Narayan A, Hunkle A, Marrone GF, Lu Z, Majumdar S, Xu J, Pan YX and Pasternak GW. Anesth Analg. 128:365-373, 2019.

Lu Z, Xu J, Xu M, Rossi GC, Majumdar S, Pasternak GW and Pan YX. Truncated mu-opioid receptors with 6 transmembrane domains are essential for opioid analgesia. Anesth Analg. 126:1050-1057, 2018.

Huang XP, Che T, Mangano TJ, Le Rouzic V, Pan YX, Majumdar S, Cameron MD, Baumann MH, Pasternak GW and Roth BL. Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo. JCI Insight. 2017 Nov 16;2(22). pii: 97222. doi: 10.1172/jci.insight.97222. [Epub ahead of print].

Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX and Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. 2017 Aug 12. pii: S0028-3908(17)30383-0. doi: 10.1016/j.neuropharm.2017.08.016. [Epub ahead of print].

Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX and Pasternak GW. Genetic dissociation of morphine analgesia from hyperalgesia in mice. Psychopharmacology. 234:1891-1900, 2017.

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People

Ying-Xian Pan

Ying-Xian Pan, MD, PhD

  • Physician-scientist Ying-Xian Pan studies the mechanisms of opioid actions, providing the foundation of developing novel drugs for pain treatment.
646-888-2167
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Members

Takeshi Irie, MD, PhD
Takeshi Irie

Assistant Attending, Anesthesiology and Critical Care

Zhigang Lu

Visiting Investigator

Yudelca Ogando
Yudelca Ogando

Senior Research Technician

Grace Rossi

Visiting Investigator

Antara Sinha
Antara Sinha

Research Fellow

Jin Xu

Research Technician

Tiffany Zhang
Tiffany Zhang

Research Technician

Lab Affiliations

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Ying-Xian Pan discloses the following relationships and financial interests:

  • American Pain Society
    Provision of Services (uncompensated)
  • Sparian Biosciences
    Ownership / Equity Interests; Provision of Services (uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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