Human Oncology & Pathogenesis Program

The Yu Chen Lab

Research

Pictured: Yu Chen
Yu Chen, MD, PhD

The major goal of my laboratory is to understand how critical transcription factors mediate prostate cancer oncogenesis. Prostate cancers uniquely harbor very few mutations in well-known driver oncogenes (e.g., RAS, BRAF, etc.). Instead, they are characterized by aberrations in transcription factors, including the androgen receptor (AR) and ETS family transcription factors. These oncogenic transcription factors regulate a transcriptional program that determines cellular lineage, specifies the responses to external stimuli, and contributes to the oncogenic cellular context in prostate cancer. Our long-term goal is to generate an integrative understanding of how transcription factors normally guide the prostate lineage determination and how their deregulation leads to cancer. In addition, using biochemistry and genetic screens, we are pursuing ways to target the activity of these transcription factors that can lead to drug discovery.

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The Chen Lab

Publications

Chen Y, Chi P, Rockowitz S, Iaquinta PJ, Shamu T, Shukla S, Gao D, Sirota I, Carver BS, Wongvipat J, Scher HI, Zheng D, Sawyers CL. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nature Medicine. In press.

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People

Pictured: Yu Chen

Yu Chen, MD, PhD

  • Physician-scientist Yu Chen studies the role of transcription factors that are critical for prostate cancer development.
  • MD, Weill Cornell Medical College
  • PhD, The Rockefeller University
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Physician profile

Members

Gabriella Bayshtok

Research Technician

Tyler Hitchman
Tyler Hitchman

Graduate Student

Dan Li

Research Fellow

Jia Ruobing

Graduate Research Assistant

Shipra Shukla
Shipra Shukla

Research Fellow

Naitao Wang

Research Fellow

Sarah Warda

Research Technician

Chen Khuan Wong

Research Fellow

Lab Alumni
Luendreo Barboza
Luendreo Barboza

Research Technician

Wei Di
Wei Di

Research Technician

Dong Gao
Dong Gao

Research Fellow

Youxin Guan
Youxin Guan

Research Technician

Samuel Kaffenberger
Samuel Kaffenberger

Research Fellow

Amanda Moore
Amanda Moore

Graduate Research Assistant

Shraddha Pancholi
Shraddha Pancholi

Research Secretary

Leili Ran, BS
Leili Ran

Investment Analyst at Superstring Capital, New York, NY

Shangqian Wang
Shangqian Wang

Graduate Research Assistant

Yu Zhan
Yu Zhan

Research Scholar

Sinan Zhu
Sinan Zhu

Research Fellow

Lab Affilations

Achievements

  • Louis V. Gerstner Young Investigator Award, Memorial Sloan Kettering Cancer Center (2011)
  • Young Investigator Award, Prostate Cancer Foundation (2011)
  • Physician Research Training Award, Department of Defense Prostate Cancer Research Program (2010)
  • Advanced Fellowship Award, Charles H. Revson Foundation (2009)
  • K08 Clinical Scientist Development Award, National Institutes of Health (2009)
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  • Clinical Scholars Award, Memorial Sloan Kettering Cancer Center (2008)
  • Young Investigator Award, American Society of Clinical Oncology (2007)
  • Clinical Cancer Research Award, American Association for Cancer Research/Bristol-Myers Squibb (2007)

Lab News & Events

Upcoming event

HOPP Research Seminar

This seminar will be conducted by Zoom Webinar.

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