Molecular Pharmacology Program

The Alex Kentsis Lab

Research

Pictured: Alex Kentsis
Alex Kentsis, MD, PhD

Our studies in cancer biology and pediatric oncology are focused on cellular plasticity, a phenomenon that relates both to the fundamental mechanisms of cancer pathogenesis and to the development of improved rational therapies. Detailed information about our research is available at http://alexkentsis.net.

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The Alex Kentsis Lab

Publications

Kentsis A. Why do young people get cancer? Pediatr Blood Cancer, 2020

Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi YY, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A. Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor. JCI Insight, 2019

Ser Z, Cifani P, Kentsis A. Optimized cross-linking mass spectrometry for in situ interaction proteomics. J Proteome Research, 2019

McNeer NA, Philip J, Geiger H, Ries RE, Lavallée VP, Walsh M, Shah M, Arora K, Emde AK, Robine N, Alonzo TA, Kolb EA, Gamis AS, Smith M, Gerhard DS, Guidry-Auvil J, Meshinchi S, Kentsis A. Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia. Leukemia, 2018 

Cifani P, Dhabaria A, Chen Z, Yoshimi A, Kawaler E, Abdel-Wahab O, Poirier JT, Kentsis A. ProteomeGenerator: A framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching. J Proteome Research, 2018 

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People

Pictured: Alex Kentsis

Alex Kentsis, MD, PhD

  • Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.
  • MD, Mount Sinai School of Medicine
  • PhD, New York University
[email protected]
Email Address
1-646-888-2593
Office Phone
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Physician profile

Members

Paolo Cifani
Paolo Cifani

Research Fellow

Daniel Cameron

Research Technician

Sandipan Roy Chowdhury

Research Fellow

Benjamin Herzberg

Clinical Fellow

Luz Jubierre Zapater, PhD
Luz Jubierre Zapater

Research Fellow

Yaniv Kazansky
Yaniv Kazansky

Graduate Student

Ross Keller
Ross Keller

Research Fellow

Shray Khanna

Research Technician

Danmeng Luo
Danmeng Luo

Research Fellow

Jack Ralls

Graduate Student

Zheng Ser

Graduate Student

Sumiko Takao

Research Fellow

Masahiro Uni
Masahiro Uni

Research Fellow

Lab Affilations

Achievements

  • Louise and Allston Boyer Award for Clinical Research
  • Terry Ann Krulwich Physician-Scientist Alumni Award (2020)
  • Pershing Square Sohn Prize
  • Leukemia & Lymphoma Society Scholar Award (2019)
  • St. Baldrick’s Robert J. Arceci Innovation Award
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  • Elected Member of American Society for Clinical Investigation
  • Society for Pediatric Research Young Investigator Award (2018)
  • Rita Allen Foundation Scholar Award
  • Damon Runyon Cancer Research Foundation Clinical Investigator Award (2016)
  • American Society of Hematology Scholar Award (2014)
  • Burroughs Wellcome Fund Career Award for Medical Scientists (2013)
  • Pediatric Hematology-Oncology Fellowship, Dana-Farber Cancer Institute
  • Residency in Pediatrics, Boston Children’s Hospital, Harvard Medical School
  • MD, PhD, Mount Sinai School of Medicine and New York University
  • AB, SM, University of Chicago

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