Cancer Biology & Genetics Program
The Andrea Ventura Lab
One of the most exciting discoveries of the last two decades has been the identification of a large number of non-coding RNAs and the realization that they play essential roles in mammalian development and in diseases. Their study and the characterization of their contribution to the pathogenesis of human cancer is the central focus of our group. To learn more about our lab, please visit our blog and webpage at: www.venturalaboratory.com.
Li X., Pritykin Y., Concepcion C.P., Lu Y., La Rocca G., Zhang M., King B., Cook P.J., Au Y. W., Popow O., Paulo J.A., Otis G.A., Mastroleo C., Ogrodowski P., Schreiner R., Haigis K.M., Betel D., Leslie C.S., Ventura A. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down Molecular Cell, June 3, 2020 https://doi.org/10.1016/j.molcel.2020.05.009 PMID:32497493
Perez AR, Pritykin Y, Vidigal JA, Chhangawala S, Zamparo L, Leslie CS, Ventura A. GuideScan software for improved single and paired CRISPR guide RNA design. Nat Biotechnol. 2017 Mar 6. doi: 10.1038/nbt.3804. [Epub ahead of print] PMID: 28263296
Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17～92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jun 1. doi: 10.1038/ng.3321. [Epub ahead of print] PubMed PMID: 26029871.
Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti, Joana A. Vidigal, Yoon-Chi Han, Paul Ogrodowski, Alessandra Crippa, Natasha Rekhtman, Elisa de Stanchina, Scott W. Lowe, and Andrea Ventura. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Oct 22.
Andrea Ventura, MD, PhD
- Cancer biologist Andrea Ventura studies non-coding RNAs in cancer and development
- MD, Catholic University of Rome (Italy)
- PhD, European Institute of Oncology (Milan Italy), Open University (London, UK)
- Postdoctoral, Center for Cancer Research, Massachusetts Institute of Technology (Cambridge, MA)
- BS, Imperial College of Science, Technology and Medicine, U. of London
- Master of Research, Imperial College of Science, Technology and Medicine, U. of London
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Andrea Ventura discloses the following relationships and financial interests:
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