Immunology Program

The Gretchen Diehl Lab

Research

Gretchen Diehl, PhD
Gretchen Diehl, PhD

The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within the intestine impair barrier repair, amplifying damage and potentially lead to systemic infection or chronic inflammatory disease including inflammatory bowel disease (IBD). We find that the intestinal microbiota and dietary factors can promote or inhibit proper immune regulation. As such, we seek to define molecular and cellular pathways regulated by the microbiota, dietary, and tissue factors that are required to maintain homeostasis within the intestine. In defining upstream signals, we are working to understand microbial pathways and how they modulate tissue immunity. In parallel, we seek to delineate how these networks are disrupted in inflammatory conditions.

The Gretchen Diehl Lab

Publications

Zegarra-Ruiz D.F., Kim D.V., Norwood K., Kim M., Wu W-J., Saldana-Morales F.B., Hill A.A., Majumdar S., Orozco, S., Bell, R., Round, J.L., Longman R.S., Egawa T., Bettini M.L.#, Diehl GE#. 2021. Thymic development of gut-microbiota-specific T cells. Nature. doi: 10.1038/s41586-021-03531-1 https://www.nature.com/articles/s41586-021-03531-1

Saldana-Morales F.B., Kim D.V., Tsai M-T., Diehl G.E., 2021. Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses. Gut Microbes. https://doi.org/10.1080/19490976.2021.1916376

Viladomiu M., Metz M.L., Lima S.F., Jin W-B., Chou L., JRI Live Cell Bank, Guo C-J., Diehl G.E., Simpson K.W., Scherl E.J., Longman R.S., 2021. Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2021.01.002

Wu, W-J.H., Zegarra-Ruiz, D.F., Diehl G.E., 2020. Intestinal microbes in autoimmune and inflammatory disease. Frontiers in Immunology. doi: 10.3389/fimmu.2020.597966 https://doi.org/10.3389/fimmu.2020.597966

Kim M., Hill A.A., Wu W-J., Diehl G.E., 2019. Intestinal microbes direct CX3CR1+ cells to balance intestinal immunity. Gut Microbes. 10: 540-546. doi: 10.1080/19490976.2018.1559683. https://doi.org/10.1080/19490976.2018.1559683

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People

Gretchen Diehl, PhD

Gretchen Diehl, PhD

  • The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.
  • PhD, University of California, Berkeley
[email protected]
Email Address

Members

Gretchen Diehl, PhD
Gretchen Diehl

Associate Member

Lin-Chun Chang
Lin-Chun Chang

Senior Research Scientist

Fatima Saldana Morales
Fatima Saldana Morales

Graduate Student

Daniel Zegarra Ruiz
Daniel Zegarra Ruiz

Postdoctoral Associate

Dasom Kim
Dasom Kim

Graduate Student

Ming-Ting Tsai
Ming-Ting Tsai

Graduate Student

Wan-Jung Wu
Wan-Jung Wu

Graduate Student

Ryann Callaghan
Ryann Callaghan

Graduate Student

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Gretchen Diehl discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


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