Immunology Program

The Justin Perry Lab

Research

Justin Perry
Justin Perry, PhD

The human body is estimated to remove 1% of its body mass, likely more than 200 billion cells, every day. To achieve this, we rely on a highly evolutionarily conserved process: apoptotic cell clearance or ‘efferocytosis’. Efferocytosis is essential for normal development and tissue homeostasis, but also pathogen defense and anti-tumor immunity. A single phagocyte typically ingests an entire apoptotic corpse, essentially doubling its content. Because phagocytes often ingest multiple targets in succession, we propose the existence of ‘rapid-response circuits’ composed of kinases that sense and activate in response to the change in a given solute, and solute transporters downstream of these kinases that impart the necessary flux of solutes. We believe these circuits allow phagocytes to handle the risk that corpse content poses to the homeostasis of both the phagocyte and ultimately the host. The central focus of our research program is to understand these rapid-response circuits governing how a phagocyte manages such excess cargo influx, how this relates to host immune function and homeostasis, and how these processes are exploited in cancer development and progression.

For more information, visit www.theperrylab.com

Research Projects

Publications

Perry, JSA*, Morioka, S*, Medina, C, Etchegaray, JI, Barron, B, Raymond, MH, Lucas, CD, Onengut-Gumuscu, S, Delpire, E, Ravichandran, KS. Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway. Nature Cell Biology. 2019, 21:1532-1543. *equal contribution.

Morioka, S*, Perry, JSA*, Raymond, MH, Medina, C, Onengut-Gumuscu, S, Ravichandran, KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. 2018, 563:714-718. *equal contribution.

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People

Justin Perry

Justin Perry, PhD

  • Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.
  • PhD, Washington University in St. Louis

Members

Pedro Saavedra
Pedro Saavedra

Postdoctoral Fellow

Waleska Saitz Rojas
Waleska Saitz Rojas

Senior Research Technician

Alissa Trzeciak
Alissa Trzeciak

Postdoctoral Fellow

Ya-Ting Wang
Ya-Ting "Emma" Wang

Postdoctoral Fellow

Zhaoquan Wang
Zhaoquan "Shasha" Wang

Graduate Student

Giulia Zago
Giulia Zago

Postdoctoral Fellow

Lab Affilations

Achievements

  • NIH/NCI Pathway to Independence Award K99/R00 (2019)
  • Burroughs Wellcome Fund – PDEP Award (2018)
  • Cancer Research Institute – Mark Foundation Postdoctoral Fellow (2018)
  • HHMI Hanna H. Gray Fellow Finalist (2017)

Open Positions

Career Opportunities

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Justin Perry discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


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This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

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