Cancer Biology & Genetics Program
The Kitai Kim Lab
The Kim lab is interested in the role that epigenetic regulation plays in pluripotency and cancer. Specifically, we are using comparative methylome studies to assess genome-wide patterns of methylation in cells derived from various tissue types and donors, including pluripotent stem cells generated via multiple methodologies. The goal of these studies is to identify the mechanisms that regulate DNA methylation and to define their contribution to the cell’s ability to self-renew, differentiate, and function normally.
Biological significance of suppression of oxidative phosphorylation in pluripotent stem cell reprogramming. Zhang C, Skamagki M, Ananthanarayanan A, Zhao R, Li H, Kim K*. Cell Reports. 2017 Nov; 21(8):2058-2065.
Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells. Liu Z, Ross CA, Khodadadi-Jamayran A, Skamagki M, Rocha ELD, Zhang W, Kong D, Chang CW, Feng J, Townes TM, Li H, Kim K*, and Zhao R. Kim K and Zhao R share co-senior-authorship. Stem Cell Reports. 2017 Nov 14;9:1-14.
Exosome-mediated control of redox status in pluripotent stem cells. Skamagki M, Zhang, C, Ross CA, Liu Z, Mu Q, Basu U, Wang J, Zhao R, Li H, Kim K*. Stem Cell Reports. 2017 Oct 10;9(4):1053-1061. PMCID: PMC5639470
ZSCAN10 expression corrects the genomic instability of iPSC from aged donors. Skamagki M, Correia C, Yeung P, Baslan T, Beck, S. Zhang, C. Ross CA, Dang L, Liu Z, Giunta S, Chang TP, Wang J, Ananthanarayanan A, Bohndorf M, Bosbach B, Adjaye J, Funabiki H, Kim J, Lowe S, Collins J, Lu CW, Li H, Zhao R, Kim K*. Nature Cell Biology. 2017 Sep;19(9):1037-1048.
Kitai Kim, PhD
- Stem cell biologist Kitai Kim studies epigenetic regulation of DNA methylation in stem cells and cancer.
- PhD, University of Wisconsin