Bess Rosen

Mentor

Education

BA, Harvard College

Bess Rosen is originally from Charleston, South Carolina. After receiving her bachelor’s from Harvard in 2011 she worked for two years as a technician in the Ikonomou lab at BU Med and for the following two years in Mriganka Sur’s lab at MIT. Having pulled herself away from Boston she joined the BCMB program at Weill Cornell in 2015. She is particularly interested in the regulation of pluripotency and signaling in pre-implantation human development. In her spare time she enjoys the great outdoors, singing, singing in the great outdoors, cheese, and puns about cheese.

Fellowships

T32 training grant in Molecular & Cell Biology (2016-2018)

Publications

CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. [PMID: 35787684]

QSER1 protects DNA methylation valleys from de novo methylation. Dixon G, Pan H, Yang D, Rosen BP, Jashari T, Verma N, Pulecio J, Caspi I, Lee K, Stransky S, Glezer A, Liu C, Rivas M, Kumar R, Lan Y, Torregroza I, He C, Sidoli S, Evans T, Elemento O, Huangfu D. Science. 2021 Apr 9;372(6538):eabd0875. doi: 10.1126/science.abd0875. [PMID: 33833093]

Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency. Li QV, Rosen BP, Huangfu D. Wiley Interdiscip Rev Syst Biol Med. 2020 Jan;12(1):e1464. doi: 10.1002/wsbm.1464.

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D. Nat Genet. 2019 Jun;51(6):999-1010. doi: 10.1038/s41588-019-0408-9.

Glutamine independence is a selectable feature of pluripotent stem cells. Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Carmona Fontaine C, Thompson CB, Finley LWS. Nat Metab. 2019 Jul;1(7):676-687. doi: 10.1038/s42255-019-0082-3.

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling. Mellios, N, Feldman, D, Sheridan, SD, Ip, JPK, Kwok, S, Amoah, S, Rosen, B, Rodriguez, B, Crawford, B, Swaminathan, R, Chou, S, Li, Y, Ziats, M, Ernst, C, Jaenisch, R, Haggarty, S, Sur, M. Molecular Psychiatry. 2017.

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Zhu Z, Li QV, Lee K, Rosen BP, González F, Soh CL, Huangfu D. Cell Stem Cell. 2016 Jun 2;18(6):755-68. doi: 10.1016/j.stem.2016.03.015.

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. Ross JS, Hu W, Rosen B, Snider AJ, Obeid LM, Cowart LA. J Biol Chem. 2013 Aug 2;288(31):22193-206. doi: 10.1074/jbc.M113.477786.