Darren Veach, PhD

Assistant Attending Chemist

Darren Veach, PhD

Assistant Attending Chemist
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Darren Veach

Tyrosine kinases often play pivotal roles in the pathogenesis of cancer and are good candidates for therapeutic intervention and targeted molecular imaging. Today’s kinase-targeted drugs are at the forefront of precision medicine and offer a much improved risk-to-benefit ratio for patients as compared to conventional chemotherapy. Companion diagnostics are often co-developed with these drugs and serve to accelerate development of these often niche drugs. A major focus of our lab is to develop these companion diagnostics, particularly for use in PET imaging, a very powerful, quantitative, non-invasive method for observing drug behavior in living systems. In our lab, many areas of medical science are brought to bear to address this challenging task: here, we operate at the nexus of molecular biology, chemistry, radiochemistry, medical physics and medicine. Here are some examples of the drugs (radiopharmaceuticals) and their indications that we are studying: