Cell Biology Program
The Meng-Fu Bryan Tsou Lab
The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses. Using quantitative proteomics, super-resolution microscopy, comparative genomics, proximity labeling, and whole genome CRISPR screen, we have identified lists of new components associated with vertebrate centrosomes and ciliogenesis. Functions of these molecules are being examined in the most appropriate experimental system, including human culture cells for cell-based assays, and most recently, mice, as the genetic system to explore the regulation specific to vertebrate ciliogenesis. This multi-system approach has revealed complex regulatory networks underlying centriole homeostasis and ciliogenesis that have been either preserved throughout the evolution or modified specifically for vertebrates and mammals.
Fong CS, Ozaki K, Tsou MB*. (2018). PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Mol Biol Cell. 29(23):2801-2808.
Yang TT, Chong WM, Wang WJ, Mazo G, Tanos B, Chen Z, Tran TMN, Chen YD, Weng RR, Huang CE, Jane WN, Tsou MB*, Liao JC*. (2018). Architecture of mammalian centriole distal appendages accommodates distinct blade and matrix functional elements. Nature Communication. 9(1):2023. (*Co-corresponding authors).
Shulman AS, Tsou MF*. (2017). Probing Cilia-Associated Signaling Proteomes in Animal Evolution. Dev Cell. 43(6):653-655.
Mazo G, Soplop N, Wang WJ, Uryu K, and Tsou MF*. (2016). Spatial control of primary ciliogenesis by subdistal appendages alters sensation-associated properties of cilia. Dev Cell. 39(4):424-437.
Kim M, O’Rourke BP, Soni RK, Jallepalli PV, Hendrickson RC, Tsou MF*. (2016). Promotion and suppression of centriole duplication are catalytically coupled through PLK4 to ensure centriole homeostasis. Cell Rep. 16(5):1195-203.
Meng-Fu Bryan Tsou, PhD
- Cell biologist Meng-Fu Bryan Tsou studies cell cycle control of centrosome duplication and degeneration, as well as cilia assembly and disassembly.
- PhD, University of California, Davis
- [email protected]
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