Molecular Pharmacology Program

The Michael Kharas Lab

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Research

Pictured: Michael Kharas
Michael G. Kharas, PhD

The Kharas lab is working to identify critical pathways in both normal and leukemic hematopoietic cells.

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VIDEO | 02:13

Inside My Lab: Michael Kharas

Go inside the lab of Michael Kharas from SKI’s Molecular Pharmacology Program.
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The Kharas Lab Group

Featured News

In the Lab
An illustration of a samurai riding a horse along a strand of RNA. The samurai’s sword is changing the letter A to the letter I.
Novel Tool Enables Study of Rare Acute Myeloid Leukemia Stem Cells

In the Lab
An illustration of two teapots with liquid flowing into various cups
How Stem Cells Decide Their Fate

In the Lab
An illustration of a samurai and a crab.
Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

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Publications

Cheng Y, Luo H, Kharas MG. Rubbing Out Leukemia Stem Cells by Erasing the Eraser. Cell Stem Cell.2020 Jul 2;27(1):3-5.

Nguyen DTT, Lu Y, Chu KL, Yang X, Park SM, Choo ZN, Chin CR, Prieto C, Schurer A, Barin E, Savino AM, Gourkanti S, Patel P, Vu LP, Leslie CS, Kharas MG. HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells. Nat Commun. 2020 Apr 24;11(1):2026.

Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Byers R, Schurer A, Gourkanti S, Bruning J, Vu L,Jaffrey S, Landau D, Kharas MG*. RNA methylation maintains hematopoietic stem cell identity and symmetric commitment. Cell Reports. 2019 August 13. 7:1703-11716.

Minuesa G, Albanese SK, Wei X, Kazansky Y, Worroll D, Chow A, Schurer A, Park S-M, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan D, Leslie C, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG*. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat. Comm. 2019 June 19; 10.

Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG.IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Cell Stem Cell.2019 Jan 3;24(1):153-165.e7.

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People

Pictured: Michael Kharas

Michael G. Kharas, PhD

  • Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.
  • PhD, University of California Irvine
[email protected]
Email Address

Members

Tatiana Erazo Andrade
Tatiana Erazo Andrade

Research Scholar

Yuanming Cheng
Yuanming Cheng

Research Scholars

Karen Chu
Karen Chu
Chiara Evans
Chiara Evans
Florisela Herrejon Chavez
Florisela Herrejon Chavez

Graduate Student

Michael Kharas, PhD
Michael Kharas

Associate Member

Hanzhi Luo
Hanzhi Luo

Research Fellow

Diu Nguyen
Diu Nguyen

Research Scholars

Sun Mi Park
Sun Mi Park

Research Associate

Thomas Rohwetter
Thomas Rohwetter
Angela Savino
Angela Savino
Anthony Velleca
Anthony Velleca
Laura Wilson
Laura Wilson

Administrative Assistant

Xuejing Yang
Xuejing Yang
Lab Alumni
Cynthia Almonte
Cynthia Almonte

Administrative Assistant

Elianna Amin

Research Fellow

Ersilia Barin
Ersilia Barin

Graduate Student at Weill Cornell

Trevor Barlowe

Research Technician

Aaron Chang

Graduate Student

Timothy Chou
Timothy Chou

Research Technician

Arthur Chow
Arthur Chow

Research Technician

Pooja Desai

Lab Intern

Gerard Minuesa Dinares , PhD
Gerard Minuesa Dinares

Biotech

Kim Do
Kim Do

Technician, Ly Vu Lab, BC Cancer Agency

Saroj Gourkanti
Saroj Gourkanti

Graduate Student at University of California, San Diego

Tzu-Chieh Kate Ho
Tzu-Chieh Kate Ho

Research Scholar

Ming Jiang

Graduate Student

Rachel Okabe

Lab Intern

Camila Prieto
Camila Prieto

Graduate Student

Alex Schurer
Alex Schurer

Medical Student at Albert Einstein

James Taggart

Research Technician

Patrick Tivnan
Patrick Tivnan

Research Technician

Ly Vu
Ly Vu

Assistant Professor, BC Cancer Agency

Lab Affilations

Achievements

  • Leukemia and Lymphoma Society Career Development Award (2017)
  • Alex Lemonade Stand Foundation ‘A’ Award (2016)
  • American Society of Hematology Junior Faculty Scholar Award (2011)
  • Kimmel Scholar Award (2013)
  • V-Scholar Award (2013)

Open Positions

Career Opportunities

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Research Technician

As a Research Technician you will perform research activities in collaboration with internal/external personnel to complete science-based projects. You will normally receive detailed instructions while making observations, analyzing data and interpreting results according to laboratory procedures. The Research Technician will provide support to all technical/research staff and postdocs.

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Michael G. Kharas discloses the following relationships and financial interests:

  • 28-7 Therapeutics
    Provision of Services (uncompensated)
  • Accent Therapeutics
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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