The Michel Sadelain Lab
My lab studies the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.
Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, Rivière I, Sadelain M. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. 2019 Apr;568(7750):112-116.
Mestermann K, Giavridis T, Weber J, Rydzek J, Frenz S, Nerreter T, Andreas M, Sadelain M, Einsele H, Hudecek M. The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells. Sci. Transl. Med. 11, eaau5907 (2019).
Feucht, F., Sun, J., Eyquem, J., Ho, Y., Zhao, Z., Leibold, J., Dobrin, A., Cabriolu, A., Hamieh, M., Sadelain, M. Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency. Nature Medicine Dec 17, 2018.
Michel Sadelain, MD, PhD
Stephen and Barbara Friedman Chair; Director, Center for Cell Engineering
- Immunologist Michel Sadelain studies the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.
- MD, University of Paris
- PhD, University of Alberta
- Inserm International Prize, Paris, France (2019)
- Jacob and Louise Gabbay Award in Biotechnology and Medicine (2019)
- Pasteur Weizmann/Servier Prize at the Academy of Sciences in Paris (2018)
- Cited in Science magazine "Breakthrough of the Year: Cancer Immunology” (2013)
- Sultan Bin Khalifa International Thalassemia Awards (SITA) International Award for Innovative Medical Research on Thalassemia (2013)
- Elected to Vice President of the American Society for Gene and Cell Therapy (Vice President 2013, President Elect 2014, President 2015)
- Antonio Cao Award for Research in Thalassemia or Hemoglobinopathies, Palermo, Italy (2013)
- Recipient of the Coley Award of the Cancer Research Institute for Distinguished Research in Tumor Immunology (shared with Carl June, University of Pennsylvania) (2012)
- Member, Grant Review Committee and Strategic Committee, CIRM (2011)
- Incumbent of the Stephen and Barbara Friedman Chair (2007)
- V Foundation Award in Honor of Mayor Rudolph Guliani (2005)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Michel Sadelain discloses the following relationships and financial interests:
Intellectual Property Rights; Ownership / Equity Interests; Provision of Services (uncompensated)
NHLBI Gene Therapy Resource Program
Provision of Services (uncompensated)
St. Jude Children's Research Hospital
Provision of Services
Intellectual Property Rights; Provision of Services
Y-mAbs Therapeutics, Inc.
Intellectual Property Rights
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This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.