Cancer Biology & Genetics Program

The Scott Lowe Lab

Research

Scott Lowe
Scott W. Lowe, PhD
Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute

About the Scott Lowe Lab

Our laboratory studies tumor-suppressor networks controlling apoptosis and senescence and how their disruption influences malignant behavior.

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Research Projects

Publications

A gene–environment-induced epigenetic program initiates tumorigenesis. Alonso-Curbelo, D, Ho, YJ, Burdziak, C, Maag, JLV, Morris IV, JP, Chandwani, R, Chen, HA, Tsanov, KM, Barriga, FM, Luan, W, Tasdemir, N, Livshits, G, Azizi, E, Chun, J, Wilkinson, JE, Mazutis, L, Leach, SD, Koche, R, Pe’er, D, Lowe, SW. Nature. 2021 Feb;590(7847):642-648. PMID: 33536616.

Senolytic CAR T Cells Reverse Senescence-Associated Pathologies. Amor, C, Feucht, J, Leibold, J, Ho, YJ, Zhu, C, Alonso-Curbelo, D, Mansilla-Soto, J, Boyer, JA, Li, X, Giavridis, T, Kulick, A, Houlihan, S, Peerschke, E, Friedman, SL, Ponomarev, V, Piersigilli, A, Sadelain, M, Lowe, SW. Nature. 2020 Jul;583(7814):127-132. PMID: 32555459.

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti, M, Morris IV, JP, Mezzadra, R, Russell, J, Leibold, J, Romesser, PB, Simon, J, Kulick, A, Ho, YJ, Fennell, M, Li, J, Norgard, RJ, Wilkinson, JE, Alonso-Curbelo, D, Sridharan, R, Heller, DA, de Stanchina, E, Stanger, BZ, Sherr, CJ, Lowe, SW. Cell. 2020 Apr 16;181(2):424-441.e21. PMID: 32234521.

α-Ketoglutarate links p53 to cell fate during tumor suppression. Morris IV, JP, Yashinskie, JJ, Koche, R, Chandwani, R, Tian, S, Chen, C-C, Baslan, T, Marinkovic, ZS, Sanchez-Rivera, FJ, Leach, SD, Carmona-Fontaine, C, Thompson, CB, Finley, LWS, Lowe, SW. Nature. 2019 Sep;573(7775):595-599. PMID: 31534224.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Ruscetti, M, Leibold, J, Bott, MJ, Fennell, M, Kulick, A, Chen, C-C, Baslan, T, Salgado, NR, Sanchez-Rivera, FJ, Tian, S, Romesser PB, Poirier, JT, Rudin, CM, de Stanchina, E, Manchado, E, Sherr, CJ, and Lowe, SW. Science. 2018 Dec 21;362(6421):1416-1422. PMID: 30573629.

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People

Scott Lowe

Scott W. Lowe, PhD

Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute

  • Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically.
  • PhD, Massachusetts Institute of Technology
[email protected]
Email Address
646-888-3342
Office Phone
Download CV
PDF File

Members

Direna Alonso Curbelo, PhD
Direna Alonso Curbelo

Postdoctoral Researcher

Corina Amor Vegas
Corina Amor Vegas

Graduate Student

Francisco Barriga, PhD
Francisco (Pancho) Barriga

Postdoctoral Researcher

Caroline Broderick
Caroline Broderick

Graduate Student

Almudena Chaves Perez
Almudena Chaves Perez

Postdoctoral Researcher

Hsuan-An Chen
Hsuan-An (Sean) Chen

Graduate Student

Yu-Jui (Ray) Ho, PhD
Yu-Jui (Ray) Ho

Computational Biologist

Margaret Kennedy
Margaret Kennedy

Graduate Student

Grace  Xiang  Li, MS
Xiang (Grace) Li

Graduate Student

Riccardo Mezzadra
Riccardo Mezzadra

Postdoctoral Researcher

S Millman, MD PhD
Scott Millman

Instructor in Medicine

Bryan Ngo
Bryan Ngo

Postdoctoral Researcher

Stella Paffenholz, MS
Stella Paffenholz

Graduate Student

José Reyes
José Reyes

Postdoctoral Researcher

Francisco Sánchez-Rivera, PhD
Francisco Sánchez-Rivera

Postdoctoral Researcher

Kaloyan Tsanov, PhD
Kaloyan Tsanov

Postdoctoral Researcher

Zeda Zhang
Zeda Zhang

Postdoctoral Researcher

Changyu Zhu
Changyu Zhu

Postdoctoral Researcher

Janelle Simon, BS
Janelle Simon

Mouse Colony Manager

Anne Trumble-Koncelik
Anne Trumble-Koncelik

Lab Manager

Wei Luan, MD
Wei Luan

Senior Research Technician

Anahi Tehuitzil
Anahi Tehuitzil

Research Technician

Vincent Tem
Vincent Tem

Research Technician

Sha Tian, MS
Sha Tian

Senior Research Technician

Alexandra Wuest
Alexandra Wuest

Research Technician

Lynn Boss, MS
Lynn Boss

Administrative Coordinator

Mei-Ling Li
Mei-Ling Li

Assistant to Chair

Lab Alumni
Iris Appelmann, MD
Iris Appelmann

Physician, University Hospital RWTH Aachen, Germany

Ana Banito, PhD
Ana Banito

Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Benedikt Bosbach, PhD
Benedikt Bosbach

Principal Scientist, CTI, Pfizer Research, New York

Chi-Chao Chen, MD
Chi-Chao Chen

Data Scientist, Agios Pharmaceuticals, Inc., Cambridge, MA

Chong Chen, PhD
Chong Chen

Professor, Sichuan University, Sichuan, China

Lukas Dow, PhD
Lukas Dow

Assistant Professor, Weill Cornell Medical College, New York, NY

Saya Ebbesen, PhD
Saya Ebbesen

Director, Medical & Scientific Strategy, BluPrint Oncology, London

Katerina Hatzi, PhD
Katerina Hatzi

Senior Scientist, Oncology Biomarker Development, Genentech, San Francisco, CA

Shauna Houlihan, PhD
Shauna Houlihan

Associate Director, Liver Research, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY

Chun-Hao Huang, PhD
Chun-Hao Huang

Co-Founder & CEO, Algen Biotechnologies, San Francisco, CA

Edward Kastenhuber, PhD
Edward (Ted) Kastenhuber

Postdoctoral Associate at Weill Cornell Medicine, New York, NY

Thomas Kitzing, PhD
Thomas Kitzing

Senior Research Scientist, Philipps University of Marburg, Institute of Pharmacology, Germany

Josef  Leibold, MD
Josef Leibold

Group Leader, University of Tübingen, Germany

Kiki Yu Liu, PhD
Yu (Kiki) Liu

Professor, Sichuan University, Sichuan, China

Geulah Livshits, PhD
Geulah Livshits

Senior Research Analyst, Biotechnology and Pharmaceuticals, Chardan Capital Markets LLC, New York, NY

Evangelia Loizou, PhD
Evangelia Loizou

Product Development Manager, NIPD Genetics, New York, NY

Amaia Lujambio, PhD
Amaia Lujambio

Associate Professor, Mount Sinai School of Medicine, New York, NY

Eusebio Manchado Robles, PhD
Eusebio Manchado Robles

Senior Principal Scientist, Novartis, Basel, Switzerland

Allison Mayle, Postdoctoral Researcher
Allison Mayle

Assistant Director, DNALC, Cold Spring Harbor Laboratory, New York

Ozlem Mert, PhD
Özlem Aksoy (née Mert)

Senior Scientist, Pfizer, San Francisco, CA

Cornelius Miething, PhD
Cornelius Miething

Group Leader and Medical Fellow, University Medical Center Freiburg, Germany

John P. Morris IV, PhD
John P. Morris IV

Assistant Professor, Department of Pharmacology, University of North Carolina, Chapel Hill, NC

Kevin P. O'Rourke, MD, PhD
Kevin P. O'Rourke

Investments, Roivant Sciences, New York, NY

Cory Rillahan, MD, PhD
Cory Rillahan

Clinical Fellow, Pediatrics, Boston Children's Hospital, Boston, MA

Marcus Ruscetti, PhD
Marcus Ruscetti

Assistant Professor, Molecular, Cell & Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Anna Saborowski, MD
Anna Saborowski

Physician, Hannover Medical School, Germany

Michael Saborowski, MD
Michael Saborowski

Physician, Hannover Medical School, Germany

Charles J Sherr
Charles J. Sherr

Chair, Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN

Nilgun Tasdemir, PhD
Nilgun Tasdemir

Senior Scientist, Functional Genomics, Target Sciences, Pfizer, New York, NY

Darjus Tschaharganeh, MD
Darjus Tschaharganeh

Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Susann Weissmueller, PhD
Susann Weissmueller

Strategic Partnering Associate, Roche, Basel, Switzerland

Zhen Zhao, MD PhD
Zhen Zhao

Pathology Resident, The Mount Sinai Hospital, New York, NY

Sarah Ackermann
Sarah Ackermann

Research Specialist, Weill Cornell Medicine, New York, NY

James H. Ahn, MS
James H. Ahn

Research Technician

Erica Anderson, BS
Erica Anderson

Research Technician

Mayerlin Chalarca
Mayerlin Chalarca

Research Technician

Ho-Chung Chen, MS
Ho-Chung Chen

Research Technician

Jonathan Fisher, BS
Jonathan Fisher

Research Technician

Danielle Grace, BS
Danielle Grace

Research Technician

Fernanda Luna, BA
Fernanda Luna

Research Technician

Jamie Plevy, BSE MS
Jamie Plevy

Research Technician

Katarzyna Rybczyk
Katarzyna (Kasia) Rybczyk

Research Technician

Aditya S. Shroff, BS
Aditya S. Shroff

Research Technician

Meredith Taylor, BS
Meredith Taylor

Research Technician

Leah  Zamechek, MS
Leah Zamechek

Laboratory Manager

Lab Affiliations

Lab News & Events

Upcoming event

Interrogating the Cancer Genome at Base Pair Resolution

This seminar will be held by Zoom webinar.

Open Positions

Postdoctoral Fellow – Leukemia Group

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Research Technician

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Get in Touch

Lab Resources

Scott Lowe Lab Plasmid and Animal Requests

Request plasmids through Addgene More »

For plasmids not listed on Addgene, please contact our Lab Manager, Anne Trumble-Koncelik, [email protected].

For animal requests, please contact our Mouse Colony Manager, Janelle Simon, [email protected].

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Scott W. Lowe discloses the following relationships and financial interests:

  • Algen
    Intellectual Property Rights
  • Blueprint Medicines
    Ownership / Equity Interests; Provision of Services
  • Constellation Pharmaceuticals
    Ownership / Equity Interests; Provision of Services
  • Eli Lilly and Company
    Provision of Services
  • Faeth Therapeutics, Inc
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Geras Bio Inc
    Ownership / Equity Interests; Provision of Services (uncompensated)
  • Mirimus
    Ownership / Equity Interests; Provision of Services
  • Oric Pharmaceuticals
    Ownership / Equity Interests; Provision of Services
  • PMV Pharma
    Ownership / Equity Interests; Provision of Services
  • Petra Pharma Corporation
    Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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