Chemical Biology Program

The Yael David Lab

Research

Yael David
Yael David, PhD

Research efforts in the David lab apply core techniques in chemical biology, biochemistry, and cell biology to address fundamental questions in the epigenetic regulation of transcription. Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and utilize chemical methods to synthesize site-specifically modified histones in vitro and in vivo and study the roles that these modifications play in disease states, with the ultimate goal of targeting them for therapeutics.

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Publications

Zheng Q, Omans ND, Leicher R, Osunsade A, Agustinus AS, Finkin-Groner E, D’Ambrosio H, Liu B, Chandarlapaty S, Liu S, David Y. Reversible histone glycation is associated with disease-related changes in chromatin architecture. Nat Commun. 2019 Mar 20;10(1):1289. doi: 10.1038/s41467-019-09192-z

Osunsade A, Prescott NA, Hebert JM, Ray DM and David Y. A Robust Method for the Purification and Characterization of the Human Histone H1 Variants. Biochemistry. 2018 Dec 26. doi: 10.1021/acs.biochem.8b01060.

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People

Yael David

Yael David, PhD

  • Yael David’s lab develops and applies methods in chemical biology toward studying epigenetic regulation and its correlation with disease states.
  • Ph.D – The Weizmann Institute of Science
  • B.Sc SUNY Stony Brook
[email protected]
Email Address
646-888-2127
Office Phone
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PDF File

Members

Yael David
Yael David

Assistant Member

Samantha Phaggoo

Administrative Assistant

Ifeh Akano
Ifeh Akano

WCM Pharmacology Graduate Student

Jakob Hebert, TPCB Graduate Student
Jakob Hebert

TPCB Graduate Student

Igor  Maksimovic
Igor Maksimovic

TPCB Graduate Student

Adewola Osunsade, TPCB Graduate Student
Adewola Osunsade

TPCB Graduate Student

Rasmus Pihl
Rasmus Pihl

Research Fellow

Nicholas Prescott, Graduate Student
Nicholas Prescott

TPCB Graduate Student

Devin Ray
Devin Ray

TPCB Graduate Student

Akhil Upad

Research Technician

Qingfei Zheng, Research Fellow
Qingfei Zheng

Research Fellow

Lab Alumni
Hannah D'Ambrosio

Research Assistant

Albert Agustinus, Research Technician
Albert Agustinus

Research Technician

Efrat Finkin, Research Associate
Efrat Finkin

Research Associate

Nathaniel Omans, Graduate Student
Nathaniel Omans

Rotation Student

Lab Affilations

Achievements

  • Pershing Square Sohn Cancer Alliance Award
  • Experimental Therapeutic Discovery Center grant
  • Specialized Program of Research Excellence (SPORE) Award
  • Josie Robertson Young Investigator’s award
  • CEBRA award

Open Positions

Graduate Students & Post-Doctoral Fellows

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Yael David discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

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