The overarching mission of the Molecular Biology Program at SKI is to understand the mechanisms that promote the integrity and expression of genetic information. Defects in the network of pathways that are integrated to preserve genome integrity are highly correlated with malignancy. This network, known as the DNA damage response, comprises DNA repair functions and DNA damage signaling, as well as the downstream outputs of signaling that include apoptosis and transcriptional changes. The focus of our genomic integrity research is on understanding the mechanisms and mediators of the various processes that make up the DNA damage response.
Researchers in our program utilize a broad range of experimental approaches such as genetics in mice, yeast, and bacteria as well as biochemistry, structural biology, and molecular biology to illuminate fundamental mechanistic features of biological processes.
Our interests include, but are not limited to:
- regulation of the cell cycle
- mechanisms that underlie accurate transmission of chromosomes during cell division
- DNA damage signaling
- mutagenesis and genome rearrangement
- mechanisms and regulation of DNA replication
- functions and metabolism of RNA
- programmed gene rearrangement pathways
- regulation of RNA repair and translation
- chromatin assembly during DNA replication and transcription
Mark S. Ptashne, PhD
Molecular biologist Mark Ptashne studies mechanisms of gene regulation.
Dirk Remus, PhD
Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.
Agnel Sfeir, PhD
The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.
Stewart Shuman, MD, PhD
The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.
Paul Tempst, PhD
Molecular biologist Paul Tempst focuses on the development of proteomic technologies and approaches for studying the eukaryotic transcriptional machineries and for cancer biomarker discovery.
Iestyn Whitehouse, PhD
Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.
Xiaolan Zhao, PhD
Molecular biologist Xiaolan Zhao studies chromosomal organization, genome integrity, DNA replication and repair, dynamic protein modification.
Collaborations & Resources
SKI offers a wide array of core facilities and other technologies, as well as significant opportunity for collaboration. Members of the Molecular Biology Program derive particular benefit from close ties to the following: