Developmental Biology Program

The Anna-Katerina Hadjantonakis Lab

Research

Pictured: Anna-Katerina Hadjantonakis
Anna-Katerina Hadjantonakis, PhD
Chair, Developmental Biology Program, SKI

Cancer is a condition arising when cells undergo an identity crisis. An understanding of how cells control their identity, and how they assemble into tissues with normal organization and function during embryonic development provides the essential blueprint for gaining insights into the fundamental biological processes that become deregulated in disease states such as cancer. 

The Hadjantonakis laboratory is interested in how individual cells become specialized, and how they collaborate at the population level to collectively build organs. Our focus is on the endoderm, the progenitor tissue that gives rise to respiratory and digestive tracts (lungs, stomach and intestines), and their associated organs such as the thyroid, thymus, liver and pancreas.

We use high-resolution quantitative methods to investigate mechanisms driving the acquisition of cell states and fates leading to the emergence of an endoderm identity, cellular platicity and differentiation, tissue organization and growth. We use the mammalian embryo and embryo-derived stem cells as experimental platforms for our studies.

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Inside My Lab: Anna-Katerina Hadjantonakis

Go inside the lab of Anna-Katerina Hadjantonakis from SKI’s Developmental Biology Program.
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Publications

Morgani SM, Su J, Nichols J, Massagué J, Hadjantonakis AK The transcription factor Rreb1 regulates epithelial architecture, invasiveness and vasculogenesis in early mouse embryos Elife. 2021 Apr 30;10:e64811. doi: 10.7554/eLife.64811. Epub ahead of print. PMID: 33929320

Simon CS, Rahman S, Raina D, Schröter C, Hadjantonakis AK. Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics.  Dev Cell. 2020 Oct 16; S1534-5807(20)30762-0. doi: 10.1016/j.devcel.2020.09.030

Saiz N, Mora-Bitria L, Rahman S, George H, Herder J, Garcia-Ojalvo J, Hadjantonakis AK.  Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development. Elife. 2020 Jul 28;9:e56079. doi: 10.7554/eLife.56079.

Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature. 2019 May;569(7756):361-367. doi: 10.1038/s41586-019-1127-1.

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People

Pictured: Anna-Katerina Hadjantonakis

Anna-Katerina Hadjantonakis, PhD

Chair, Developmental Biology Program, SKI

  • The Hadjantonakis laboratory studies pluripotency, cell lineage commitment, tissue patterning, and morphogenesis in mammalian embryos and in vitro stem cell models.
  • PhD, Imperial College (London)
[email protected]
Email Address
212-639-3159
Office Phone

Members

Kat Hadjantonakis, PhD
Kat Hadjantonakis

Member

Abderhman Abuhashem
Abderhman Abuhashem

Graduate Student

Sayali Chowdhary

Postdoctoral Research Scholar

Nicole Clerico
Nicole Clerico

Administrative Assistant

Alexandre Francou
Alexandre Francou

Postdoctoral Research Associate

Vidur Garg
Vidur Garg

Postdoctoral Research Scholar

Rocío Hernández-Martínez
Rocío Hernández-Martínez

Senior Research Scientist

Ying-Yi Kuo
Ying-Yi Kuo

Research Assistant

Kavya Mehndiratta
Kavya Mehndiratta

Research Technician

James Muller
James Muller

Advanced Imaging Specialist - Manager of Light Microscope Cluster

Sonja Nowotschin, PhD
Sonja Nowotschin

Senior Research Scientist

Jonathan Pai
Jonathan Pai

Graduate Student

Clayton Schwarz
Clayton Schwarz

Research Fellow – joint with Dr. Eric Siggia at Rockefeller University

Lab Alumni
Jerome Artus

Postdoctoral Research Fellow

Sophie Balmer
Sophie Balmer

Postdoctoral Research Fellow

Evan Bardot
Evan Bardot

Postdoctoral Research Fellow

John Burrowes

Administrative Assistant

Lydia Coleman
Lydia Coleman

Administrative Assistant

Anna Ferrer-Vaquer

Postdoctoral Research Fellow

Laina Freyer
Laina Freyer

Postdoctoral Research Fellow

Benjamin Gordon
Benjamin Gordon

Research Technician

Minjung Kang, BS
Minjung Kang

Graduate Student

Xinghua Lou

Postdoctoral Research Fellow

Sophie Morgani
Sophie Morgani

Research Fellow - joint with Dr. Jenny Nichols at Cambridge University

Silvia Munoz-Descalzo

Visiting Research Fellow

Ricky Narvaez
Ricky Narvaez

Research Technician

Yvonne Pao

Research Technician

Anna Piliszek

Postdoctoral Research Fellow

Berenika Plusa

Visiting Research Fellow

Maria Pulina

Postdoctoral Research Fellow

Nestor Saiz Arenales, PhD
Nestor Saiz Arenales

Postdoctoral Research Fellow

Kristy Schmicking

Administrative Assistant

Nadine Schrode
Nadine Schrode

Graduate Research Assistant

Claire Simon

Postdoctoral Research Fellow

Rowena Turnbull

Research Technician

Manuel Viotti

Graduate Student

Evan Weiner

Research Technician

Tao Wu, PhD
Tao Wu

Postdoctoral Research Fellow

Panos Xenopoulos

Postdoctoral Research Fellow

Lab Affiliations

Open Positions

Postdoctoral Fellow Position

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Anna-Katerina Hadjantonakis discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


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This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

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