Developmental Biology Program
The Anna-Katerina Hadjantonakis Lab
Cancer is a condition arising when cells undergo an identity crisis. An understanding of how cells control their identity, and how they assemble into tissues with normal organization and function during embryonic development provides the essential blueprint for gaining insights into the fundamental biological processes that become deregulated in disease states such as cancer.
The Hadjantonakis laboratory is interested in how individual cells become specialized, and how they collaborate at the population level to collectively build organs. Our focus is on the endoderm, the progenitor tissue that gives rise to respiratory and digestive tracts (lungs, stomach and intestines), and their associated organs such as the thyroid, thymus, liver and pancreas.
We use high-resolution quantitative methods to investigate mechanisms driving the acquisition of cell states and fates leading to the emergence of an endoderm identity, cellular platicity and differentiation, tissue organization and growth. We use the mammalian embryo and embryo-derived stem cells as experimental platforms for our studies.
Morgani SM, Su J, Nichols J, Massagué J, Hadjantonakis AK The transcription factor Rreb1 regulates epithelial architecture, invasiveness and vasculogenesis in early mouse embryos Elife. 2021 Apr 30;10:e64811. doi: 10.7554/eLife.64811. Epub ahead of print. PMID: 33929320
Simon CS, Rahman S, Raina D, Schröter C, Hadjantonakis AK. Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics. Dev Cell. 2020 Oct 16; S1534-5807(20)30762-0. doi: 10.1016/j.devcel.2020.09.030
Saiz N, Mora-Bitria L, Rahman S, George H, Herder J, Garcia-Ojalvo J, Hadjantonakis AK. Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development. Elife. 2020 Jul 28;9:e56079. doi: 10.7554/eLife.56079.
Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature. 2019 May;569(7756):361-367. doi: 10.1038/s41586-019-1127-1.
Anna-Katerina Hadjantonakis, PhD
Chair, Developmental Biology Program, SKI
- The Hadjantonakis laboratory studies pluripotency, cell lineage commitment, tissue patterning, and morphogenesis in mammalian embryos and in vitro stem cell models.
- PhD, Imperial College (London)
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Anna-Katerina Hadjantonakis discloses the following relationships and financial interests:
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