The Christopher Lima Lab: Projects

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The Christopher Lima Lab
Post-Translational Protein Modification by Ubiquitin-like Proteins
Ubiquitin-like proteins (Ubls) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular interactions. Conjugation is achieved through a cascade of activities that are catalyzed by E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. We are focused on understanding how Ubl conjugation pathways achieve selectivity for particular targets, and how conjugation generates signals in processes ranging from DNA repair to the cell cycle.
The Christopher Lima Lab
RNA Decay
RNA quantity and quality are regulated by a balance between transcription and degradation. We have focused on characterizing the activities of the RNA exosome, an essential multi-subunit protein complex that catalyzes 3' to 5' process or decay of nearly every class of cellular RNA in the nucleus and cytoplasm.
The Christopher Lima Lab
Other Interests
Past interests of the laboratory included studies to address RNA processing and repair as well as antioxidant defense pathways in Mycobacterium tuberculosis.