Morgan Huse: Publications

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Zhang, M., Zhao, Z., Pritykin, Y., Hannum, M., Scott, A. C., Kuo, F., Sanghvi, V., Chan, T. A., Seshan, V., Wendel, H.-G., Schietinger, A., Sadelain, M., and Huse, M. (2021). Ectopic Activation of the miR200c-EpCAM Axis Enhances Anti-tumor T Cell Responses in Models of Adoptive Cell Therapy. Sci. Transl. Med. 13, eabg4328. 

Tello-Lafoz, M., Srpan, K., Sanchez, E. E., Hu, J., Remsik, J., Romin, Y., Calò, A., Hoen, D., Bhanot, U., Morris, L., Boire, A., Hsu, K. C., Massagué, J., Huse, M.*, and Er, E. E.* (2021) Cytotoxic Lymphocytes Target Characteristic Biophysical Vulnerabilities in Cancer. Immunity 54, 1037-1054.  * corresponding authors

Chaudhuri, P. K., Wang, M. S., Black, C. T., Huse. M., and Kam, L. C. (2020). Modulating T Cell Activation Using Depth Sensing Topographic Cues. Adv. Biosyst. 4, e2000143.

Santich, B. H., Park, J. A., Tran, H., Huse, M., and Cheung, N. V. (2020). Interdomain Spacing and Spatial Configuration Drive the Potency of IgG-[L]-scFv T Cell Bispecific Antibodies. Sci. Trans. Med. 12, eaax1315.

Tamzalit, F., Tran, D., Jin, W., Boyko, V., Bazzi, H., Kepecs, A., Kam., L. C., Anderson, K. V., and Huse, M. (2020). Centrioles Control the Capacity, but not the Specificity, of Cytotoxic T Cell Killing. Proc. Nat. Acad. Sci. USA 117, 4310-4319.

Vorselen, D., Wang, Y., De Jesus, M., Shah, P., Footer, M. J., Huse, M., Cai, W., and Theriot, J. A. (2020). Microparticle Traction Force Microscopy Reveals Subcellular Force Exertion Patterns in Immune Cell-Target Interactions. Nat. Commun. 11, 20.

Jin, W., Tamzalit, F., Chaudhuri, P. K., Black, C. T., Huse, M., and Kam, L. C. (2019). T cell Activation and Immune Synapse Organization Respond to the Microscale Mechanics of Structured Surfaces. Proc. Nat. Acad. Sci. USA 116, 19835-19840.

Sanchez, E., Liu, X., and Huse, M. (2019). Actin Clearance Promotes Polarized Dynein Accumulation at the Immunological Synapse. PLoS One 14, e0210377.

Adams, N. M., Geary, C. D., Santosa, E. K., Lumaquin, D., Le Luduec, J. B., Sottile, R., van der Ploeg, K., Hsu, J., Whitlock, B. M., Jackson, B. T., Weizman, O. E., Huse, M., Hsu, K.C., and Sun, J. C. (2019). Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity 50, 1381-1390.

Hamieh, M., Dobrin, A., Cabriolu, A., van der Stegen, S. J. C., Giavridis, T., Mansilla-Soto, J., Eyquem, J., Zhao, Z., Whitlock, B. M., Miele, M. M., Li, Z., Cunanan, K. M., Huse, M., Hendrickson, R. C., Wang, X., Riviere, I., and Sadelain, M. (2019). CAR T Cell Trogocytosis and Cooperative Killing Regulate Tumor Antigen Escape. Nature 568, 112-116.

Tamzalit, F., Wang, M. S., Jin, W., Tello-Lafoz, M., Boyko, V., Heddleston, J. M., Black, C. T., Kam, L. C., and Huse, M. (2019). Interfacial Actin Protrusions Mechanically Enhance Killing by Cytotoxic T Cells. Sci. Immunol., eaav5445.

Sanchez, E., and Huse, M. (2018). Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist. J. Vis. Exp. 134, e56655.

Tello-Lafoz, M., Martinez-Martinez, G., Rodriquez-Rodriguez, C., Albar, J.P., Huse, M., Gharbi, S., and Merida, I. (2017). SNX27 Interactome in T Lymphocytes Identifies ZO-2 Dynamic Redistribution at the Immune Synapse. Traffic 18, 491-504.

Oyler-Yaniv, A., Oyler-Yaniv, J., Whitlock, B. M., Liu, Z., Germain, R. N., Huse, M., Altan-Bonnet, G., and Krichevsky, O. (2017). A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity 46, 609-620.

Jin, W., Black, C. T., Kam, L. C., and Huse, M. (2017). Probing Synaptic Biomechanics Using Micropillar Arrays. In Cosima T. Baldari (Ed.), Methods in Molecular Biology, the Immune Synapse (pp. 333-346). Switzerland: Springer.

Huse, M. (2017). Mechanical Forces in the Immune System. Nat. Rev. Immunol. 17, 679-690.

Basu, R., and Huse, M. (2016). Mechanical Communication at the Immunological Synapse. Trends Cell Bio. 27, 241-254.

Cheng, M., Santich, B., Xu, H., Ahmed, M., Huse, M., and Cheung, N. V. (2016). Successful Engineering of a Highly Potent Single-Chain-Variable-Fragment (scFv) Bispecific Antibody to Target Disialoganglioside (GD2) Positive Tumors. Oncoimmunology 5, e1168557.

Basu, R., Whitlock, B. M., Husson, J., Le Floc’h, A., Jin, W., Oyler-Yaniv, A., Dotiwala, F., Giannone, G., Hivroz, C., Biais, N., Lieberman, J., Kam, L. C., and Huse, M. (2016). Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell 165, 100-110.

Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. R., and Li, M. O. (2016). Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell 164, 365-377.

Nguyen Duc, T., and Huse, M. (2015). A Generalizable Platform for the Photoactivation of Cell Surface Receptors. ACS Chem. Bio. 10, 2435-2440.

Huse, M. (2014). Lipid-based Patterning of the Immunological Synapse. Biochem. Soc. Trans. 42, 1506-1511.

Chauveau, A., Le Floc’h, A., Bantilan, N. S., Koretzky, G. A., and Huse, M. (2014). Diacylglycerol Kinase α Establishes T Cell Polarity by Shaping Diacylglycerol Accumulation at the Immunological Synapse. Sci. Signal. 7, ra82.

Bashour, K. T., Gondarenko, A., Chen, H., Shen, K., Liu, X., Huse, M., Hone, J. C., and Kam, L. C. (2014). CD28 and CD3 Have Complementary Roles in T-cell Traction Forces. Proc. Nat. Acad. Sci. USA 111, 2241-2246.

Le Floc’h, A. Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y., and Huse, M. (2013). Annular PIP3 Accumulation Controls Actin Architecture and Modulates Cytotoxicity at the Immunological Synapse. J. Exp. Med. 210, 2721-2737.

Liu, X., Kapoor, T. M., Chen, J. K., and Huse, M. (2013). Diacylglycerol Promotes Centrosome Polarization in T Cells via Reciprocal Localization of Dynein and Myosin II. Proc. Nat. Acad. Sci. USA 110, 11976-11981.